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LX-4211

CAS No.: 1018899-04-1

Chemical Name:: LX-4211

Synonyms: Sotagliflozin;β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034;LX421;LX-4211;CS-1853;SOTA-009;LP 802034;EOS-61381;LX4211/LX-4211

CBNumber:: CB52516025

Molecular Formula:: C21H25ClO5S

Molecular Weight:: 424.94

MOL File:: 1018899-04-1.mol

Modify Date:: 2024/7/2 8:55:11

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LX-4211 Properties

Boiling point	607.9±55.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM) Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM)
pka	12.87±0.70(Predicted)
form	Powder
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Warning

Hazard statements

H351-H373

Precautionary statements

P201-P202-P281-P308+P313-P405-P501-P260-P314-P501

NFPA 704

	0
2		0

LX-4211 Chemical Properties,Uses,Production

Uses

Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.

Clinical Use

Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption.

Synthesis

Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Synthesis_1018899-04-1
Sotagliflozin synthesis

LX-4211 Preparation Products And Raw materials

Raw materials

Preparation Products

LX-4211 Suppliers

Global( 247)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	985	58	Inquiry
Apeloa production Co.,Limited	+8619933239880	China	853	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Apeloa production Co.,Limited	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

How to synthesize Sotagliflozin?
Sotagliflozin (LX-4211) is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (....
Jan 16，2024

LX-4211 Spectrum

LX-4211(1018899-04-1)¹HNMR

1018899-04-1(LX-4211)Related Search:

Dapagliflozin Empagliflozin D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Tofogliflozin Ipragliflozin

Canagliflozin

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LX-4211 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside LX4211/LX-4211 LP 802034 LX4211 - L10525 LX-4211 (sotagliflozin) LX-4211, >=98% Zabofloxacin Hydrochloride Sotagliflozin,0.99 β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-, (5S)- LX4211/Sotagliflozin-API Sotagliflozin, must LX4211, 98%, a potent dual SGLT2/1 inhibitor Sotagliflozin lx4211 LX421 SOTA-009 (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol EOS-61381 LX4211; LX 4211; LX4211; LX 4211 CS-1853 (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2-H-pyran-3,4,5-triol Sotagliflozin (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034 β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)- UNII-6B4ZBS263Y Bifeprunox Impurity 42 Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034 LX-4211|||LP-802034 1018899-04-1 C21H25ClO5S C21H25O5ClS