21-HYDROXYALLOPREGNANOLONE
- CAS No.
- 567-02-2
- Chemical Name:
- 21-HYDROXYALLOPREGNANOLONE
- Synonyms
- TDOC;5α-THDOC;ALLO TH DOC;3α,5α-THDOC;5alpha-THDOC;ALLOTETRAHYDRO DOC;ALLOTETRAHYDROCORTEXONE;1-HYDROXYALLOPREGNANOLONE;21-HYDROXYALLOPREGNANOLONE;ALLOTETRAHYDRO SUBSTANCE 'Q'
- CBNumber:
- CB5265066
- Molecular Formula:
- C21H34O3
- Molecular Weight:
- 334.49
- MOL File:
- 567-02-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/10/28 13:29:47
21-HYDROXYALLOPREGNANOLONE price More Price(2)
21-HYDROXYALLOPREGNANOLONE Chemical Properties,Uses,Production
Uses
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:
- as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
- to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
- in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury
General Description
3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.
Biochem/physiol Actions
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.
21-HYDROXYALLOPREGNANOLONE Preparation Products And Raw materials
Raw materials
Preparation Products
21-HYDROXYALLOPREGNANOLONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4086 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32080 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30241 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8467 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52925 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131957 | 58 | Inquiry |
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| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | China | 9305 | 58 | Inquiry |
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 18561885118 | China | 3944 | 58 | Inquiry |
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