Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >EI1

EI1

EI1 Structure
CAS No.
1418308-27-6
Chemical Name:
EI1
Synonyms
EI1;CS-2378;EI1;EI 1;KB-145943;EI1 USP/EP/BP;EI1;EI-1;EI 1;EI1 (KB145943;Ezh2 inhibitor;EI1 (Ezh2 inhibitor;Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943
CBNumber:
CB52655403
Molecular Formula:
C23H26N4O2
Molecular Weight:
390.48
MOL File:
1418308-27-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

EI1 Properties

Boiling point 675.9±55.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
form Powder
pka 11.88±0.10(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312

EI1 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 5.00561 Ezh2 Inhibitor II, EI1 - CAS 1418308-27-6 - Calbiochem 1418308-27-6 10MG ₹22390 2022-06-14 Buy
Product number Packaging Price Buy
5.00561 10MG ₹22390 Buy

EI1 Chemical Properties,Uses,Production

Description

EZH2 is a histone methyltransferase and its activation leads to alteration in cell cycle regulation, proliferation, and cancer progression [65]. High expression and mutation of EZH2 are in a variety of malignancies and usually portend for a poor prognosis.

Pharmacology

EZH2 has been shown to repress the cell cycle inhibitor p21 and other proapoptotic factors, thereby promoting cell cycling in SCLC cells. In various SCLC cell lines, suppression of EZH2 leads to reduction of cells in S, G2/M phase with increased p21 expression. EZH2 was also shown to prevent apoptosis by inhibition of TGF-β via histone methyltransferase methylation of lysine 27?in histone H3 (H3K27me3). In addition, it has been shown that in platinum-resistant cancer cells, protein and mRNA expression EZH2 is upregulated and by silencing EZH2 overcomes drug resistance, making EZH2 a target of interest in SCLC.

EI1 Preparation Products And Raw materials

Raw materials

Preparation Products

EI1 Suppliers

Global( 73)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-29-87569265 +86-18612256290 China 2132 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24639 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 China 9771 58 Inquiry
Shanghai Qiming Biological Technology Co., Ltd. 021-61483491 CHINA 6503 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Shaanxi Dideu Medichem Co. Ltd 58
Dideu Industries Group Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Zeye Biotechnology Co., Ltd. 58
Shanghai Qiming Biological Technology Co., Ltd. 58

EI1 Spectrum

EI1(1418308-27-6)1HNMR

1418308-27-6(EI1)Related Search:

Sulfanilamide N,N'-Ethylenebis(stearamide) Deionized water 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Sodium cyanoborohydride
S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Imatinib mesylate Dasatinib LDN212854 Docetaxel
1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide
chevron_left

1of3

chevron_right
EI1 Ezh2 inhibitor 6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide EI1;EI-1;EI 1 6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide CS-2378 EI1 (Ezh2 inhibitor EI1;EI 1 KB-145943 1H-Indole-4-carboxamide, 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)- EI1 USP/EP/BP EI1 (KB145943 Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943 1418308-27-6 Inhibitors API