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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Structure
CAS No.
1185503-48-3
Chemical Name:
(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
Synonyms
Aprepitant intermediate 1;Fosaprepitant Impurity 31;Aprepitant Impurity 12 HCl;Aprepitant intermediate 1 HCl;Arepitam intermediate 1 hydrochloride;Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe;Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
CBNumber:
CB52669000
Molecular Formula:
C20H18F7NO2
Molecular Weight:
437.35
MOL File:
1185503-48-3.mol
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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Properties

Boiling point 387.9±42.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
pka 6.93±0.60(Predicted)

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Chemical Properties,Uses,Production

Uses

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Suppliers

Global( 35)Suppliers
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Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
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Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
ANHUI WITOP BIOTECH CO., LTD 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shanghai Zerui Biotechnology Co., Ltd. 58
Hubei Ruinuo Pharmaceutical Technology Co., Ltd 58
QUALITY CONTROL SOLUTIONS LTD. 58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd 58
BOC Sciences 65
Shanghai jerryxing Biomedical Technology Co., Ltd 58

1185503-48-3((2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride)Related Search:

Aprepitant Impurity 17 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine Aprepitant Aprepitant
Fosaprepitant Impurity 6 [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Aprepitant
Fosaprepitant Impurity 5 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane Aprepitant
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine
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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)- Aprepitant intermediate 1 HCl Aprepitant intermediate 1 Arepitam intermediate 1 hydrochloride Fosaprepitant Impurity 31 Aprepitant Impurity 12 HCl (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe 1185503-48-3