WZB117
- CAS No.
- 1223397-11-2
- Chemical Name:
- WZB117
- Synonyms
- WZB-117;CS-2648;WZB-117 >=98% (HPLC);WZB117;WZB-117;WZB 117;Glucose Transporter Inhibitor IV, WZB117;3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate);3-Hydroxy-benzoic acid 1,1′-(3-fluoro-1,2-phenylene) ester;Benzoic acid, 3-hydroxy-, 1,1'-(3-fluoro-1,2-phenylene) ester;Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem
- CBNumber:
- CB52750588
- Molecular Formula:
- C20H13FO6
- Molecular Weight:
- 368.31
- MOL File:
- 1223397-11-2.mol
- Modify Date:
- 2023/7/14 17:27:29
| Boiling point | 628.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.431±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 8.96±0.10(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may br stored at -20° for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| WGK Germany | 3 |
WZB117 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0621 | WZB-117 ≥98% (HPLC) | 1223397-11-2 | 5MG | ₹12394.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0621 | WZB-117 ≥98% (HPLC) | 1223397-11-2 | 25MG | ₹49589.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 400036 | Glucose Transporter Inhibitor IV, WZB117 - CAS 1223397-11-2 - Calbiochem The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter. | 1223397-11-2 | 25MG | ₹20650 | 2022-06-14 | Buy |
WZB117 Chemical Properties,Uses,Production
Uses
WZB 117 is a GLUT1 inhibitor.
General Description
A bis-hydroxybenzoate compound that acts as a fast-acting, irreversible blocker of glucose transport by GLUT1 in red blood cells. Shown to rapidly inhibit glucose transport in cancer cells (IC50 ~ 500 nM in A549 cells) and block proliferation. Its inhibitory effects are more pronounced in hypoxic cancer cells. It binds directly to GLUT1 involving three hydrogen bonds, one each with Asn34, Arg126, and Trp412. Also shown to reduce the levels of GLUT1 protein, intracellular ATP levels, and glycolytic enzymes and increase the level of AMPK in tumor cells. Preferentially induces cell cycle arrest and causes senescence and necrosis in red blood cells and tumor cells (IC50 = 10 μM) over non cancerous cells and synergizes the anti-tumor effects of cisplatin (Cat. No. 232120) and paclitaxel (Cat. No. 580555). Also, effectively suppresses tumor growth in human A549 lung cancer grafted nude mice model (10 mg/kg, i.p., daily).
Biochem/physiol Actions
Cell permeable: yes
WZB117 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20290 | 58 | Inquiry |
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