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(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

CAS No.: 77943-39-6

Chemical Name:: (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Synonyms: (4R,5S)-4-Methyl-5-phenyloxazolidin-2-one;(4S,5S)-4-Methyl-5-phenyloxazolidin-2-one;TB-2039;4-methyl-5-phenyl-2-oxazolidinone;5β-Phenyl-4β-methyloxazolidine-2-one;4α-Methyl-5α-phenyloxazolidine-2-one;4-Methyl-5-phenyl-1,3-oxazolidin-2-one;(4R-5S)-4-Methyl-5-Phenyl-2-Oxazocidin;(4R,5S)-4-Methyl-5-phenyl-2-oxazolidone;(4R,5S)-4-Methyl-4-phenyl-2-oxazolidone

CBNumber:: CB5321737

Molecular Formula:: C10H11NO2

Molecular Weight:: 177.2

MOL File:: 77943-39-6.mol

MSDS File:: SDS

Modify Date:: 2023/5/25 10:25:51

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(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE Properties

Melting point	121-123 °C(lit.)
Boiling point	309.12°C (rough estimate)
Density	1.1607 (rough estimate)
refractive index	1.5168 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Liquid
pka	12.35±0.60(Predicted)
color	Clear colorless to yellow-brown, may darken in storage
optical activity	[α]18/D +168°, c = 2 in chloroform
BRN	1211705
InChI	InChI=1S/C10H11NO2/c1-7-9(13-10(12)11-7)8-5-3-2-4-6-8/h2-7,9H,1H3,(H,11,12)/t7-,9-/m1/s1
InChIKey	PPIBJOQGAJBQDF-VXNVDRBHSA-N
SMILES	O1[C@@H](C2=CC=CC=C2)[C@@H](C)NC1=O
CAS DataBase Reference	77943-39-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	N
Safety Statements	22-24/25
WGK Germany	3
HS Code	29349990

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	298891	(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone 99%	77943-39-6	5G	₹16920	2022-06-14	Buy

Product number	Packaging	Price	Buy
298891	5G	₹16920	Buy

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(4R,5S)-4-Methyl-5-phenyloxazolidinone is used as effective chiral auxiliary for conjugate addition asymmetric synthesis of (-)-aplysillamide B.

Preparation

To a solution of (1S,2R)-norephedrine (40 g, 0.26 mol) in toluene (400 mL) was added diethyl carbonate (37 mL, 0.32 mol). The mixture was heated to reflux (under Ar) while 40 mL of solvent was removed through the use of a Dean–Stark apparatus. The mixture was allowed to cool for 20 min, and then sodium methoxide (1 g) was added. Upon reheating, an EtOH/toluene azeotropic mixture was removed at 75–77 °C. After 3 h, the reaction was complete and the temperature of the mixture had increased to 125 °C. The mixture was left to stand at room temperature for 16 h, whereupon (4R,5S)-4-methyl-5-phenyloxazolidin-2-one (40.6 g) crystallized and could be collected. The solvent was removed from the filtrate in vacuo and the residue was redissolved in EtOAc (250 mL). This solution was washed with brine (50 mL) and a precipitate was removed by filtration. The solvent was then removed in vacuo and toluene (50 mL) was added to the residue. Removal of the toluene by distillation yielded oily crystals of the oxazolidinone, which were washed with Et2O to afford 4.5 g (total 45 g, 97%).

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

N-CROTONYL-(4R,5S)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE Suppliers

Global( 139)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Malladi Drugs AND Pharmaceuticals Limited	+91-9004653310 +91-9003056437	Tamil Nadu, India	69	58	Inquiry
Embio Limited	+91-9004390567 +91-9004390567	Maharashtra, India	33	58	Inquiry
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EMBIO LIMITED	+91 22 6679 7200	New Delhi, India	14	58	Inquiry
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MALLADI DRUGS AND PHARMACEUTICALS LTD	044 – 66876900	New Delhi, India	44	58	Inquiry

Supplier	Advantage
Malladi Drugs AND Pharmaceuticals Limited	58
Embio Limited	58
EMMELLEN BIOTECH PHARMACEUTICALS LTD	61
OCEAN TRADING CORPORATION	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
EMBIO LIMITED	58
Manus Aktteva Biopharma LLP	58
Reax Chemicals	58
MALLADI DRUGS AND PHARMACEUTICALS LTD	58

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE Spectrum

(4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE(77943-39-6)¹HNMR (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE(77943-39-6)IR (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE(77943-39-6)FT-IR (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE(77943-39-6)Raman

77943-39-6((4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE)Related Search:

(R)-(+)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE (R)-4,5,5-TRIPHENYL-2-OXAZOLIDINONE (R)-(+)-5,5-DIPHENYL-4-BENZYL-2-OXAZOLIDINONE (4S,5R)-(-)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE

Oxazole 2-Oxazolidone N-ACETYL-(4S,5R)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE (2R,4S)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone N-CROTONYL-(4S,5R)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE,N-CROTONYL-(4S,5R)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE

(R)-(+)-5,5-DIPHENYL-4-METHYL-2-OXAZOLIDINONE (4R,5R)-4-Methyl-5-phenyl-2-oxazolidinone ,(4R,5R)-4-Methyl-5-phenyl-2-oxazolidinone (4S,5S)-4-Methyl-5-phenyl-2-oxazolidinone ,(4S,5S)-4-Methyl-5-phenyl-2-oxazolidinone N-PROPIONYL-(4S,5R)-4-METHYL- 5-PHENYL-2-OXAZOLIDINONE (R)-(+)-5,5-DIPHENYL-4-ISOBUTYL-2-OXAZOLIDINONE

(4R,5S)-(+)-CIS-4,5-DIPHENYL-2-OXAZOLIDINONE N-CROTONYL-(4R,5S)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE,N-CROTONYL-(4R,5S)-4-METHYL 5-PHENYL-2-OXAZOLIDINONE (2S,4R)-3-Benzoyl-4-methyl-2-phenyl-5-oxazolidinone

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(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone 99% 4-Methyl-5-phenyl-1,3-oxazolidin-2-one (4R,5S)-(-)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (4R,5S)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE (4R,5S)-4-Methyl-5-phenyl-2-oxazolidone (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLID -INONE, 99% (99% EE/GLC) (4R,5S)-4-METHYL-5-PHENYL-2-OXAZOLIDI DI NONE 2-Oxazolidinone, 4-methyl-5-phenyl-, (4R,5S)- 4-methyl-5-phenyl-2-oxazolidinone (4S)-4β-Methyl-5α-phenyloxazolidine-2-one 5β-Phenyl-4β-methyloxazolidine-2-one (4R)-4α-Methyl-5α-phenyloxazolidin-2-one 4α-Methyl-5α-phenyloxazolidine-2-one (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone,99% (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidine (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone ,98% (4R,5S)-(+)-4-METHYL-5-PHENYL-2-OXAZOLIDINONE USP/EP/BP (4R,5S)-4-Methyl-5-phenyl-1,3-oxazolidin-2-one (4S,5S)-4-Methyl-5-phenyloxazolidin-2-one (4R,5S)-4-Methyl-5-phenyloxazolidin-2-one TB-2039 (4R-5S)-4-Methyl-5-Phenyl-2-Oxazocidin (4R,5S)-4-Methyl-4-phenyl-2-oxazolidone 77943-39-6 Chiral Auxiliaries Asymmetric Synthesis Oxazolidinone Derivatives chiral Peptide