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Isosilybin

CAS No.: 72581-71-6

Chemical Name:: Isosilybin

Synonyms: Q-100795;Isosilybin;Isosilybinin;ISOSILIBININ;indissolubly;Isosilybin，ISB;ISOSILYBIN hplc;Diosmin Impurity 24;Isosilybin USP/EP/BP;Isosilybin(Mixture A&B)

CBNumber:: CB5359479

Molecular Formula:: C25H22O10

Molecular Weight:: 482.44

MOL File:: 72581-71-6.mol

Modify Date:: 2024/4/16 13:02:56

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Isosilybin Properties

Boiling point	793.0±60.0 °C(Predicted)
Density	1.527±0.06 g/cm3(Predicted)
storage temp.	Store at -20° C
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.1 mg/ml
pka	7.39±0.60(Predicted)
form	Solid
color	White-light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312+P330-P501

NFPA 704

	0
2		0

Isosilybin Chemical Properties,Uses,Production

Description

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC₅₀ = 32 μM) and reduces ADP/Fe³⁺-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

Uses

Isosilybin is useful in the treatment of liver disease

Definition

The flavonolignan isosilybin is one of the components of the flavonoid complex extracted from the seeds of Silybum marianum (milk thistle), designated silymarin. Besides isosilybin, silymarin contains other flavonoids (congeners), such as silybin, 2,3-dehydrosilybin, silydianin, silychristin, isosilychristin, and taxifolin and ca. 20–30% is an undefined polymeric phenolic fraction. However, several recent studies have demonstrated that isosilybin is probably the most potent anticancer agent in silymarin. Isosilybin was shown to possess in vivo anti-proliferative, anti-angiogenic, pro-apoptotic, and cell-cycle modulatory properties. Moreover, isosilybin and especially isosilybin B inhibited the growth of advanced human prostate cancer cells in vivo without any toxic effects[1].

Definition

ChEBI: A flavonolignan isolated from Silybum marianum.

References

[1] Radek Ga?ák . “Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture.” Process Biochemistry 48 1 (2013): Pages 184-189.

Isosilybin Preparation Products And Raw materials

Raw materials

Preparation Products

Isosilybin Suppliers

Global( 171)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3772	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49403	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29821	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23555	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	23499	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	China	25363	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
PNP Biotech Co. Ltd	+8618516098983	China	1001	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
TargetMol Chemicals Inc.	58
PNP Biotech Co. Ltd	58

72581-71-6(Isosilybin)Related Search:

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ISOSILIBININ ISOSILYBIN(PRIMARY STANDARD) Isosilybinin Isosilybin (Isosilybinin) (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one ISOSILYBIN hplc Isosilybin (A+B) mixture -(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one Isosilybin 4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)- Q-100795 Isosilybin (Mixture of Diastereomers) Isosilybin，ISB Isosilybin USP/EP/BP indissolubly Isosilybin(Mixture A&B) Diosmin Impurity 24 (2R,3R)-3,5,7-Trihydroxy-2-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one 72581-71-6 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Miscellaneous Natural Products Intermediates & Fine Chemicals Pharmaceuticals