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5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid

5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid Structure
CAS No.
1797983-23-3
Chemical Name:
5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid
Synonyms
Mesalamine Impurity 2;Mesalazine Impurity 2;Mesalamine Impurity S;Mesalazine EP Impurity S;Mesalamine EP Impurity S;Mesalazine (Mesalamine) EP Impurity S;Mesalazine Impurity 11(Mesalazine EP Impurity S);5-amino-2-[(3-carboxy-4-hydroxyphenyl)amino]benzoic acid;5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid;2-Hydroxy-5-[(2-carboxy-4-aminophenyl)amino]benzoic Acid
CBNumber:
CB53649322
Molecular Formula:
C14H12N2O5
Molecular Weight:
288.26
MOL File:
1797983-23-3.mol
Modify Date:
2023/7/14 17:31:21

5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid Properties

Melting point >180°C (dec.)
Boiling point 542.6±50.0 °C(Predicted)
Density 1.590±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 2.85±0.36(Predicted)
color Yellow to Dark Green
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid Chemical Properties,Uses,Production

Uses

2-Hydroxy-5-Amino-N-(2-carboxy-4-aminophenyl)benzoic Acid is an impurity from the synthesis of Mesalamine (M258100).

5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(4-amino-2-carboxyphenyl)amino]-2-hydroxybenzoic acid 5-amino-2-[(3-carboxy-4-hydroxyphenyl)amino]benzoic acid Mesalazine EP Impurity S Mesalazine Impurity 11(Mesalazine EP Impurity S) Mesalamine Impurity (2-Hydroxy-5-amino-N-(2-carboxy-4-aminophenyl)benzoic Acid) Mesalazine Impurity 2 Mesalamine Impurity 2 Mesalamine EP Impurity S Benzoic acid, 5-amino-2-[(3-carboxy-4-hydroxyphenyl)amino]- Mesalazine (Mesalamine) EP Impurity S 2-Hydroxy-5-Amino-N-(2-carboxy-4-aminophenyl)benzoic Acid (>90%) 2-Hydroxy-5-[(2-carboxy-4-aminophenyl)amino]benzoic Acid Mesalamine Impurity S 5-Amino-2-((3-carboxy-4-hydroxyphenyl)amino)benzoic acid (Mesalazine/Mesalamine Impurity) 1797983-23-3