2,6-Difluorobenzamide
- CAS No.
- 18063-03-1
- Chemical Name:
- 2,6-Difluorobenzamide
- Synonyms
- 2,6-difluorobenzoic acid amide;uorobenzamide;2,6-Difluorbenzamid;2,6-DIFLUOROBENZAMIDE;2,6-difluoro-benzamid;2，6-difluorobenzaminde;2,6-Difluorobenzoamide;2,6-Difluorobenzamide>2,6-Difluorobenzoylamide;2,6-Difluorobenzamide97%
- CBNumber:
- CB5376515
- Molecular Formula:
- C7H5F2NO
- Molecular Weight:
- 157.12
- MOL File:
- 18063-03-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/3 18:47:13
| Melting point | 145-148 °C (lit.) |
|---|---|
| Boiling point | 51-52C/15Tor |
| Density | 1,199g/cm |
| refractive index | 1,508 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble5%, clear to turbid, colorless to light yellow |
| pka | 14.54±0.50(Predicted) |
| form | Solid |
| color | Off-White |
| BRN | 2047480 |
| InChIKey | AVRQBXVUUXHRMY-UHFFFAOYSA-N |
| LogP | 0.011-0.25 at 25℃ |
| CAS DataBase Reference | 18063-03-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzamide, 2,6-difluoro-(18063-03-1) |
| EPA Substance Registry System | Benzamide, 2,6-difluoro- (18063-03-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20 | |||||||||
| Safety Statements | 26-37/39-36/37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CV4355050 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Toxicity | rat,LC50,inhalation,> 2100mg/m3/4H (2100mg/m3),National Technical Information Service. Vol. OTS0543293, | |||||||||
| NFPA 704 |
|
2,6-Difluorobenzamide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 282278 | 2,6-Difluorobenzamide 97% | 18063-03-1 | 10G | ₹3074.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 282278 | 2,6-Difluorobenzamide 97% | 18063-03-1 | 50G | ₹5802.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D1907 | 2,6-Difluorobenzamide min. 98.0 % | 18063-03-1 | 25G | ₹3200 | 2022-05-26 | Buy |
| ALFA India | ALF-A11685-14 | 2,6-Difluorobenzamide, 98+% | 18063-03-1 | 25g | ₹2988 | 2022-05-26 | Buy |
| ottokemi | D 1806 | 2,6-Difluorobenzamide+ 97% | 18063-03-1 | 10gm | ₹2808 | 2022-05-26 | Buy |
2,6-Difluorobenzamide Chemical Properties,Uses,Production
Description
2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.
Description
2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].
Chemical Properties
white to yellowish powder
Uses
2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.
Preparation
2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
References
[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.
2,6-Difluorobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Advantage |
|---|---|
| SNECOFRi Pvt Ltd | 58 |
| CNS CHEMICALS | 58 |
| Aarti Industries Limited (AIL) | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Dr R R Organics | 58 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |