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Boc-Hyp-OH

CAS No.: 13726-69-7

Chemical Name:: Boc-Hyp-OH

Synonyms: (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;BOC-HYP-OH;BOC-HYP;BOC-L-HYP-OH;N-BOC-L-HYDROXYPROLINE;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;(2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylic Acid;N-ter;Teneint-E;oc-L-Hyp-OH

CBNumber:: CB5411793

Molecular Formula:: C10H17NO5

Molecular Weight:: 231.25

MOL File:: 13726-69-7.mol

MSDS File:: SDS

Modify Date:: 2024/8/26 21:18:56

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Boc-Hyp-OH Properties

Melting point	123-127 °C(lit.)
Boiling point	390.9±42.0 °C(Predicted)
alpha	-78 º (in H2O)
Density	1.312±0.06 g/cm3(Predicted)
refractive index	-68 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	3.80±0.40(Predicted)
form	Powder
color	White to off-white
optical activity	[α]20/D 53.5±2°, c = 1% in DMF
Water Solubility	very faint turbidity
BRN	4295484
InChIKey	BENKAPCDIOILGV-RQJHMYQMSA-N
CAS DataBase Reference	13726-69-7(CAS DataBase Reference)
EPA Substance Registry System	(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

22-24/25

WGK Germany

HS Code

2933 99 80

HazardClass

IRRITANT

NFPA 704

	1
1		0

Boc-Hyp-OH price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	8.53026	Boc-Hyp-OH (cryst) Novabiochem?	13726-69-7	25G	₹25940	2022-06-14	Buy
Sigma-Aldrich(India)	8.53026	Boc-Hyp-OH (cryst) Novabiochem?	13726-69-7	100G	₹77250	2022-06-14	Buy
Sigma-Aldrich(India)	15544	Boc-Hyp-OH ≥98.0% (TLC)	13726-69-7	5G	₹5477.45	2022-06-14	Buy
Sigma-Aldrich(India)	15544	Boc-Hyp-OH ≥98.0% (TLC)	13726-69-7	25G	₹18846.33	2022-06-14	Buy
TCI Chemicals (India)	B1635	trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline	13726-69-7	5G	₹5800	2022-05-26	Buy

Product number	Packaging	Price	Buy
8.53026	25G	₹25940	Buy
8.53026	100G	₹77250	Buy
15544	5G	₹5477.45	Buy
15544	25G	₹18846.33	Buy
B1635	5G	₹5800	Buy

Boc-Hyp-OH Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Biological Activity

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Boc-Hyp-OH Preparation Products And Raw materials

Raw materials

Preparation Products

N-Boc-4-oxo-L-Proline methyl ester 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-BOC-cis-4-fluoro-L-proline H-Hyp(Bzl)-OH · HCl

tert-butyl (S)-7-oxohexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (2S,4R)-1-(tert-butoxycarbonyl)-4-((2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yl)oxy)pyrrolidine-2-carboxylicacid

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Boc-Hyp-OH Suppliers

Global( 492)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
BTC pharm India	+918790379245	AndhraPradesh, India	1269	58	Inquiry
SURVIVAL TECHNOLOGIES LIMITED	+91 8108285261	Gujarat, India	294	58	Inquiry
BTC pharm India	+918790379245	Telangana, India	145	58	Inquiry
VGS SYNTHESIS PRIVATE LIMITED	+91-9866975588 +91-9866975588	Hyderabad, India	1818	58	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry
Malladi Drugs AND Pharmaceuticals Limited	+91-9004653310 +91-9003056437	Tamil Nadu, India	69	58	Inquiry
ARRKEM LIFE SCIENCES PRIVATE LIMITED	+91-8148739767 +91-8148739767	Telangana, India	260	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry

Supplier	Advantage
BTC pharm India	58
SURVIVAL TECHNOLOGIES LIMITED	58
BTC pharm India	58
VGS SYNTHESIS PRIVATE LIMITED	58
JSK Chemicals	58
Malladi Drugs AND Pharmaceuticals Limited	58
ARRKEM LIFE SCIENCES PRIVATE LIMITED	58
TCI Chemicals (India) Pvt. Ltd.	58
A.J Chemicals	58
Maas Pharma Chemicals	58

Boc-Hyp-OH Spectrum

Boc-L-Hydroxyproline(13726-69-7)MS Boc-L-Hydroxyproline(13726-69-7)¹³CNMR Boc-L-Hydroxyproline(13726-69-7)IR1 Boc-L-Hydroxyproline(13726-69-7)IR2

13726-69-7(Boc-Hyp-OH)Related Search:

L-Hydroxyproline BOC-D-PHE-OSU Boc-D-Valine 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Methyl N-(tert-butoxycarbonyl)-L-threoninate

Boc-L-serine methyl ester BOC-GUANIDINE BOC-L-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,BOC-HYP-OME / BOC-L-HYDROXYPROLINE METHYL ESTER BOC-HYP(BZL)-OH 1-Boc-L-hydroxyproline ethyl ester

N-Boc-trans-4-tosyloxy-L-proline methyl ester (2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER Boc-Hyp-OH BOC-CIS-HYDROXYPROLINE-OME L-Proline

(2S,4R)-BOC-4-(2-NAPHTHYLMETHOXY)-PYRROLIDINE-2-CARBOXYLIC ACID BOC-HYP-OH DCHA (2S,4R)-BOC-4-(2-NAPHTHYLOXY)-PYRROLIDINE-2-CARBOXYLIC ACID

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(2S,4R)-N-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic Acid Boc-(2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic Acid N-ter N-(tert-Butoxycarbonyl)-trans-4-hydroxy-L-proline ,98% Boc-L-trans-hydroxyproline(Boc-trans-Hyp-OH) ,98.5%(HPLC) 1,2-Pyrrolidinedicarboxylicacid,4-hydroxy-,1-(1,1-diMethylethyl)ester,(2S,4R)- (2S)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid trans-N-Boc-4-hydroxy-L-proline trans-Boc-Hyp-OH (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester (2S,4R)-1-(tertbutoxycarbonyl-4-hydroxypyrrolidine acid Boc-Hyp-OH, >=98.0% trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline N-Boc-(2S,4R)-4-hydroxyproline BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID BOC-L-HYDROXYPROLINE BOC-L-4-HYDROXYPROLINE BOC-HYDROXYPROLINE BOC-TRANS-HYP-OH BOC-TRANS-4-HYDROXY-L-PROLINE BOC-L-T-4-HYDROXYPROLINE BOC-L-TRANS-4-HYDROXYPROLINE Boc-L-trans-4-hydroxyproline≥ 99% (Assay) Boc-Hyp-OH (cryst) Novabiochem Boc-Hyp-OH >=98.0% (TLC) (2S,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID RARECHEM EM WB 0136 N-T-BOC-TRANS-4-HYDROXY-L-PROLINE N-(TERT-BUTOXYCARBONYL)-L-4-HYDROXYPROLINE N-TERT-BUTOXYCARBONYL-L-HYDROXYPROLINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE N-ALPHA-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINE （2S，4R)-1-（tertbutoxycarbonyl）-4-hydroxypyrrolidine carboxylic acid BOC-HYPOZANTHINE extrapure Boc-L-hydroxyproline, trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline trans-Boc-Hyp-OH trans-N-Boc-4-hydroxy-L-proline 1-[(tert-Butoxy)carbonyl]-4-hydroxy-L-proline N-ALPHA-T-BOC-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-T-BUTOXYCARBONYL-L-HYDROXYPROLINE N-ALPHA-T-BOC-L-HYDROXYPROLINE N-ALPHA-T-BOC-L-TRANS-4-HYDROXYPROLINE N-BOC-TRANS-4-HYDROXY-L-PROLINE N-BOC-L-4-HYDROXYPROLINE N-BOC-L-TRANS-4-HYDROXYPROLINE N-BOC-4-HYDROXY-L-PROLINE TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY-L-PROLINE Butoxycarbonylhydroxypyroline Boc-4-hydroxy-L-proline TRANS-N-(TERT-BUTOXYCARBONYL)-4-HYDROXY- N-(TERT-BUTOXYCARBONYL)-L-4-HYDROXYPROLINEBOC-L-HYP-OH TERT-BUTYLOXYCARBONYLHYDROXYPROLINE 4-hydroxy-1-tert-butoxycarbonyl-pyrrolidine-2-carboxylic acid N-ALPHA-T-BUTYLOXYCARBONYL-L-4-HYDROXYPROLINE BOC TRANS 4 HYDROXY L PROLINE, METHYL ESTER (BOC H NALPHA-tert-Butoxycarbonyl-trans-4-hydroxy-L-proline N-tert-Butoxycarbonyl-Trans-4-hydroxy-L-proline (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Animal Origin) (Tert-Butoxy)Carbonyl Hyp-OH (Hyp of Non-Animal Origin)