L-Hydroxyproline
![L-Hydroxyproline Structure](CAS/GIF/51-35-4.gif)
- CAS No.
- 51-35-4
- Chemical Name:
- L-Hydroxyproline
- Synonyms
- TRANS-4-HYDROXY-L-PROLINE;HYDROXYPROLINE;(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;Hyp;4-Hydroxyproline;4-HYDROXY-L-PROLINE;H-HYP-OH;4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;HYDROXY-L-PROLINE;4R-4-hydroxyproline
- CBNumber:
- CB8357870
- Molecular Formula:
- C5H9NO3
- Molecular Weight:
- 131.13
- MOL File:
- 51-35-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/8 18:06:34
Melting point | 273 °C (dec.)(lit.) |
---|---|
alpha | -75.5 º (c=5, H2O) |
Boiling point | 242.42°C (rough estimate) |
Density | 1.3121 (rough estimate) |
vapor density | 4.5 (vs air) |
refractive index | -75.5 ° (C=4, H2O) |
storage temp. | Store below +30°C. |
solubility | H2O: 50 mg/mL |
form | Crystals or Crystalline Powder |
pka | 1.82, 9.66(at 25℃) |
color | White |
PH | 5.5-6.5 (50g/l, H2O, 20℃) |
Odor | Odorless |
optical activity | [α]25/D 75.6°, c = 1 in H2O |
Water Solubility | 357.8 g/L (20 º C) |
Merck | 14,4840 |
BRN | 471933 |
InChIKey | PMMYEEVYMWASQN-DMTCNVIQSA-N |
LogP | -0.350 (est) |
CAS DataBase Reference | 51-35-4(CAS DataBase Reference) |
NIST Chemistry Reference | Hydroxyproline(51-35-4) |
EPA Substance Registry System | trans-4-Hydroxy-L-proline (51-35-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P271-P280 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36/37/38-22 | |||||||||
Safety Statements | 24/25-36/37/39-27-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TW3586500 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29339990 | |||||||||
NFPA 704 |
|
L-Hydroxyproline price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | H5534 | trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% | 51-35-4 | 10MG | ₹2955.23 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H5534 | trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% | 51-35-4 | 25G | ₹23522.73 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H5534 | trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% | 51-35-4 | 100G | ₹63066.45 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR1939 | Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material | 51-35-4 | 500MG | ₹15826.15 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | H5534 | trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% | 51-35-4 | 1KG | ₹319705.55 | 2022-06-14 | Buy |
L-Hydroxyproline Chemical Properties,Uses,Production
Description
A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.
Chemical Properties
White crystalline powder
Uses
A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
Production Methods
In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.
Definition
ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Purification Methods
Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]
L-Hydroxyproline Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_rightSupplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
BTC pharm India | +918790379245 | Telangana, India | 145 | 58 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
Parth Antibiotics Pvt Ltd. | +91 (22) 2562-8329 | New Delhi, India | 173 | 50 | Inquiry |
Lalchand Bhimraj Group | 91-44-25354424 | Tamil Nadu, India | 50 | 58 | Inquiry |
Yasham Speciality ingredients Pvt Ltd | 91-22-40639900 | Maharashtra, India | 42 | 58 | Inquiry |
Supplier | Advantage |
---|---|
BTC pharm India | 58 |
JSK Chemicals | 58 |
BTC pharm India | 58 |
CHEMSWORTH | 30 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
Scientific OEM | 38 |
ALPHA CHEMIKA | 43 |
Parth Antibiotics Pvt Ltd. | 50 |
Lalchand Bhimraj Group | 58 |
Yasham Speciality ingredients Pvt Ltd | 58 |
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