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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Proline derivatives >L-Hydroxyproline

L-Hydroxyproline

L-Hydroxyproline Structure
CAS No.
51-35-4
Chemical Name:
L-Hydroxyproline
Synonyms
TRANS-4-HYDROXY-L-PROLINE;HYDROXYPROLINE;(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;Hyp;4-Hydroxyproline;4-HYDROXY-L-PROLINE;H-HYP-OH;4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;HYDROXY-L-PROLINE;4R-4-hydroxyproline
CBNumber:
CB8357870
Molecular Formula:
C5H9NO3
Molecular Weight:
131.13
MOL File:
51-35-4.mol
MSDS File:
SDS
Modify Date:
2024/11/19 23:02:33
Request For Quotation

L-Hydroxyproline Properties

Melting point 273 °C (dec.)(lit.)
alpha -75.5 º (c=5, H2O)
Boiling point 242.42°C (rough estimate)
Density 1.3121 (rough estimate)
vapor density 4.5 (vs air)
refractive index -75.5 ° (C=4, H2O)
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form Crystals or Crystalline Powder
pka 1.82, 9.66(at 25℃)
color White
PH 5.5-6.5 (50g/l, H2O, 20℃)
Odor Odorless
optical activity [α]25/D 75.6°, c = 1 in H2O
Water Solubility 357.8 g/L (20 º C)
Merck 14,4840
BRN 471933
InChIKey PMMYEEVYMWASQN-DMTCNVIQSA-N
LogP -0.350 (est)
CAS DataBase Reference 51-35-4(CAS DataBase Reference)
NIST Chemistry Reference Hydroxyproline(51-35-4)
EPA Substance Registry System trans-4-Hydroxy-L-proline (51-35-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
RTECS  TW3586500
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339990
NFPA 704
1
0 0

L-Hydroxyproline price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) H5534 trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% 51-35-4 10MG ₹2955.23 2022-06-14 Buy
Sigma-Aldrich(India) H5534 trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% 51-35-4 25G ₹23522.73 2022-06-14 Buy
Sigma-Aldrich(India) H5534 trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% 51-35-4 100G ₹63066.45 2022-06-14 Buy
Sigma-Aldrich(India) PHR1939 Hydroxyproline Pharmaceutical Secondary Standard; Certified Reference Material 51-35-4 500MG ₹15826.15 2022-06-14 Buy
Sigma-Aldrich(India) H5534 trans-4-Hydroxy-L-proline BioReagent, suitable for cell culture, ≥98.5% 51-35-4 1KG ₹319705.55 2022-06-14 Buy
Product number Packaging Price Buy
H5534 10MG ₹2955.23 Buy
H5534 25G ₹23522.73 Buy
H5534 100G ₹63066.45 Buy
PHR1939 500MG ₹15826.15 Buy
H5534 1KG ₹319705.55 Buy

L-Hydroxyproline Chemical Properties,Uses,Production

Description

A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

Chemical Properties

White crystalline powder

Uses

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

Production Methods

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

Definition

ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

L-Hydroxyproline Preparation Products And Raw materials

Raw materials

Soy bean Isoflavone Isoflavone 10-40% Α-protein Bone glue Casein Gelatin

Preparation Products

N-Boc-cis-4-Hydroxy-L-proline methyl ester (R)-(-)-3-Pyrrolidinol hydrochloride (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride N-Boc-4-oxo-L-Proline methyl ester
Fmoc-L-hydroxyproline 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-methyl-, 1,1-dimethylethyl ester, (2S,4S)- 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- BETONICINE
TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER 1-BENZYLPYRROLE 1-PHENYLPYRROLE
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L-Hydroxyproline Suppliers

Global( 989)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BTC pharm India +918790379245 AndhraPradesh, India 1262 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3753 58 Inquiry
BTC pharm India +918790379245 Telangana, India 143 58 Inquiry
Pallav Chemicals And Solvents Pvt Ltd +91-9136093115 +91-9136093115 Maharashtra, India 1364 58 Inquiry
ARRAKIS INDUSTRIES LLP +91 74995 32711 Maharashtra, India 1353 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
Scientific OEM +91-22- 2343 7546 / 2341 3094 New Delhi, India 1994 38 Inquiry
ALPHA CHEMIKA +91-22-22061123 +91-22-66382501 Mumbai, India 1679 43 Inquiry
Parth Antibiotics Pvt Ltd. +91 (22) 2562-8329 New Delhi, India 173 50 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6700 30 Inquiry
Supplier Advantage
BTC pharm India 58
JSK Chemicals 58
BTC pharm India 58
Pallav Chemicals And Solvents Pvt Ltd 58
ARRAKIS INDUSTRIES LLP 58
TCI Chemicals (India) Pvt. Ltd. 58
Scientific OEM 38
ALPHA CHEMIKA 43
Parth Antibiotics Pvt Ltd. 50
CHEMSWORTH 30

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51-35-4(L-Hydroxyproline)Related Search:

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(S)-(-)-TRANS-4-HYDROXYPROLINE FOR SYNTH trans-4-Hydroxy-L-proline, 99+% 10GR trans-4-Hydroxy-L-proline, 99+% 25GR trans-4-Hydroxy-L-proline Microbial, cell culture tested 4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID 4-HYDROXY-L-PROLINE TRANS ISOMER (S)-(-)-TRANS-4-HYDROXYPROLINE RARECHEM EM WB 0135 TRANS-L-HYDROXYPROLINE TRANS-L-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 4-L-Hydroxyproline delta-Hydroxyproline L-Proline, 4-hydroxy-, trans- L-Proline,4-hydroxy-,trans Ls-Hydroxyproline Proline, 4-hydroxy- Proline, 4-hydroxy-, L- trans-Hydroxyproline (-)-(2S,4R)-4-Hydroxyproline L-Hypro (4R)-4-Hydroxy-L-proline (4R)-4β-Hydroxy-L-proline 2-Hydroxy-L-proline 2-Hydroxyproline L-Hydroxyproline 〔trans-4-Hydroxy-L-proline〕 L-Hydroxyproline 〔trans-4-Hydroxy-L-proline〕, Animal-Free trans-L-4-Hydroxyproline≥ 99% (Titration) trans-L-4-HydroxyprolineNon-animal Japanese origin99.0-101.0% (Assay, dry basis) trans-4-Hydroxy-L-proline,99%e.e. TRANS-4-HYDROXY-L-PROLINE BIOXTRA, > (S)-(-)-trans-4-Hydroxyproline for synthesis [2S,4S]-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID (2S,4R)-(-)-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID H-HYP-OH (TRANS) H-L-HYDROXYPROLINE H-L-HYP-OH H-TRANS-HYP-OH HYDROXY-L-PROLINE, TRANS-4- HYDROXYPROLINE, L- L-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID L-4-TRANS-HYDROXYPROLINE L-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID L-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS-ISOMER L4-4-HYDROXY-2-PYRROLIDINE-CARBOXYLIC ACID TRANS ISOMER L-TRANS-4-HYDROXYPROLINE L-HYDROXYPROLINE (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acidHyp 4-hydroxy-L-proline (trans) TRANS-4-HYDROXY-L-PROLINE, 99+% L-HydroxyprolineForBiochemistry L-Hydroxyproline99+% L-HYDROXYPROLINE ( AKA ) TRANS 4 HYDROXY L PROLINE TRANS 4 HYDROXY L PROLINE (HYPRO) TRANS-L-HYDROXYPROLINE, (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECARBOXYLIC ACID L-HYDROXY PROLINE/TRANS-L-4-HYDROXYPROLINE L-HYDROXYPROLINE51-35-4 HYDROXY-L-PROLINE, trans-4-(RG)