ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >Allopregnanolone
Allopregnanolone
- CAS No.
- 516-54-1
- Chemical Name:
- Allopregnanolone
- Synonyms
- Brexanolone;ALLOPREGNANOLONE;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;5α-P;ASN16541;3α-OH-DHP
- CBNumber:
- CB5418550
- Molecular Formula:
- C21H34O2
- Molecular Weight:
- 318.49
- MOL File:
- 516-54-1.mol
- Modify Date:
- 2024/1/8 14:13:41
| Melting point | 176-178° |
|---|---|
| alpha | D +87.7° (abs alc) |
| Boiling point | 431.2±18.0 °C(Predicted) |
| Density | 1.053±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | chloroform: 20 mg/mL, clear, colorless |
| pka | 15.12±0.70(Predicted) |
| form | White solid |
| color | white |
| Merck | 13,272 |
| BRN | 3211363 |
| Stability | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | AURFZBICLPNKBZ-SYBPFIFISA-N |
| CAS DataBase Reference | 516-54-1(CAS DataBase Reference) |
Allopregnanolone price More Price(2)
Allopregnanolone Chemical Properties,Uses,Production
Description
Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.
Uses
(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.
Biological Activity
GABA A receptor positive allosteric modulator. Neuroactive steroid.
Allopregnanolone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 224)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5959 | 58 | Inquiry |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | China | 294 | 58 | Inquiry |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | China | 1090 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
Related articles
- How to synthesize Brexanolone？
- Developed by Sage Therapeutics, brexanolone was approved by the USFDA as a first-in-class treatment for PPD in adult women.
- Jan 8，2024
516-54-1(Allopregnanolone)Related Search:
ALLOPREGNANOLONE(RG)
21-HYDROXYALLOPREGNANOLONE
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE
ALLOTETRAHYDROCORTISOL
ALLOTETRAHYDROCORTICOSTERONE
chevron_left
1of4
chevron_right
1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
3-A-5-A-TETRAHYDROPROGESTERONE
3-alpha,5-alpha-pregnanolone
3α-OH-DHP
Allopregnan-3a-ol-20-one
(3α)-Allopregnanolone
3α,5α-Tetrahydroprogesterone
3α,5α-THP
3α-Hydroxy-5α-dihydroprogesterone
3α-Hydroxy-5α-pregnane-20-one
5α-P
3-alpha,5-alpha-tetrahydroprogesterone
3-alpha-hydroxy-5-alpha-pregnan-20-on
5alpha-Pregnan-20-one, 3alpha-hydroxy-
Pregnan-20-one, 3-hydroxy-, (3alpha,5alpha)-
5ALPHA-PREGNAN-3ALPHA-OL-20-ONE
3ALPHA-HYDROXY-5ALPHA-20-ONE
3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-ONE
3ALPHA-OH-DHP
ALLOPREGNAN-3ALPHA-OL-20-ONE
1-[(3R,5S,8R,9S,10S,13R,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
5a-Pregnan-3alpha-ol-3-one
3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP, Allopregnan-3α-ol-20-one
(3alpha,5alpha)-3-hydroxypregnan-20-one
Alpha - Pregnan - alpha - 3 ol - twenty - one, Brexanolone
5α-Pregnan-3α-ol-20-one
(3α,5β)-3-Hydroxy-pregnan-20-one
Allopregnan-3α-ol-20-one
(3alpha)-Allopregnanolone
1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10
5alpha progesterone 3alpha alcohol 20 one (tetrahydro progesterone)
Allopregnan-3 alpha-ol-20-one，Allopregnanolone
3α,5α-THP
(3α)-Allopregnanolone
Allopregnanolone(Brexanolone)
LJPC-0712
3Α;5Α-THP; SAGE547; SAGE 547; SAGE-547
3A-HYDROXY-5A-PREGNAN-20-ONE
Allopregnanolone - CAS 516-54-1 - Calbiochem
Brexanolone（SAGE-547）
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
5alpha-Pregnan-3alpha-ol-20-one,3α-hydroxy-5α-pregnan-20-one
5alpha-Pregnan-3a-ol-20-one
Allopregnanolone (Solution)
5alpha-Pregnan-3alpha-ol-20-one,Brexanolone
Anlotinib Dihydrochloride
allotetrahydroprogesterone
ALLOPREGNANOLONE
3α-hydroxy-5α-pregnan-20-one
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one
Brexanolone
(3a)-Allopregnanolone
3α-hydroxy-5α-pregnan-20-one
3α-Hydroxy-AlloProgesterone
Brexanolone/Allopregnan-3alpha-ol-20-one
Allopregnalone
Pregnan-20-one, 3-hydroxy-, (3α,5α)-
ALLOPREGNANOLONE