OLVANIL
- CAS No.
- 58493-49-5
- Chemical Name:
- OLVANIL
- Synonyms
- Ovanil;OLVANIL;NE-19550;N-VANILLYLOLEAMIDE;N-VANILLYLOLEOYLAMIDE;N-Vannilyloleoylamide;(n-vanillyl)-9-oleamide;N-VANILLYL-9-OCTADECENAMIDE;Olvanil (cis- and trans- mixture);N-(4-Hydroxy-3-methoxybenzyl)oleamide
- CBNumber:
- CB5461006
- Molecular Formula:
- C26H43NO3
- Molecular Weight:
- 417.62
- MOL File:
- 58493-49-5.mol
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RG2242130 | |||||||||
| NFPA 704 |
|
OLVANIL Chemical Properties,Uses,Production
Description
Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex interactions with the cannabinoid system, in that it potentiates the agonist activity of endogenous cannabinoids by inhibiting the reuptake of arachidonyl ethanolamide (AEA). Olvanil is a more potent reuptake inhibitor than AM404, which is commonly used for this purpose (50% inhibition of reuptake at 10 μM versus 12% for AM404 at the same dose). Olvanil is also a CB1 agonist, but does not bind to CB2 receptors or inhibit fatty acid amide hydrolase. The overall activity of olvanil in most models is that of an analgesic, but it is unclear how these effects are mediated by VR1, the CB1 receptor, or other components of the endogenous pain sensation system.
Uses
Olvanil is a TRPV1 agonist more potent than capsaicin.
Biological Activity
Potent vanilloid receptor agonist (pEC 50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC 50 = 9 μ M) and may bind to CB 1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
OLVANIL Preparation Products And Raw materials
Raw materials
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OLVANIL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48465 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | China | 3433 | 58 | Inquiry |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | China | 62163 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24647 | 58 | Inquiry |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | China | 2999 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry |
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