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Pemigatinib

CAS No.: 1513857-77-6

Chemical Name:: Pemigatinib

Synonyms: IBI-375;INCB54828;INCB 54828;INCB-54828;INCB-054828;Pemigatinib;2H8]-Pemigatinib;Pemigatinib, 10 mM in DMSO;Terbufos Impurity 14 (Ethion);INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic

CBNumber:: CB54796678

Molecular Formula:: C24H27F2N5O4

Molecular Weight:: 487.5

MOL File:: 1513857-77-6.mol

Modify Date:: 2024/7/24 13:33:21

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Pemigatinib Properties

Boiling point	697.6±55.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
form	A crystalline solid
pka	11.56±0.40(Predicted)
color	White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Pemigatinib Chemical Properties,Uses,Production

Uses

Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.

Indications

Pemigatinib is indicated for the treatment of previously treated adult patients with unresectable locally advanced or metastatic cholangiocarcinoma (CCA) who have been identified by an FDA-approved test for the presence of fibroblast growth factor receptor 2 (FGFR2) fusions or other rearrangements.

brand name

Pemazyre

General Description

Class: receptor tyrosine kinase; Treatment: metastatic cholangiocarcinoma; Other name: INCB054828; Elimination half-life = 15 h; Protein binding = 90.6%

target

Primary targets: Pan-FGFR

IC 50

FGFR1/2/3/4 IC 50 = 0.4, 0.5, 1, 30 nM

Pemigatinib Preparation Products And Raw materials

Raw materials

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-7-(phenylsulfonyl)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-7-(phenylsulfonyl)- 1H-Pyrrolo[2,3-b]pyridine-5-methanamine, N-(2,6-difluoro-3,5-dimethoxyphenyl)-4-(ethylamino)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro- 4-(ethylamino)-1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde

4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE

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Preparation Products

Pemigatinib Suppliers

Global( 128)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6514	58	Inquiry
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	China	485	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	33024	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19552	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32202	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10473	58	Inquiry
Henan Alfa Chemical Co., Ltd	+8615838112936	China	13194	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6391	58	Inquiry
Beijing Mesochem Technology Co.,Ltd	+8613651027935	China	191	58	Inquiry
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	China	923	58	Inquiry

Supplier	Advantage
SynZeal Research Pvt Ltd	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Henan Alfa Chemical Co., Ltd	58
InvivoChem	58
Beijing Mesochem Technology Co.,Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58

How is Pemigatinib Synthesised?
Pemigatinib is synthesised using pyrrolopyridine as a raw material, firstly by synthesis of Pemigatinib Morpholine Intermediat....
Jan 2，2024

Pemigatinib Spectrum

Pemigatinib(1513857-77-6)¹HNMR

1513857-77-6(Pemigatinib)Related Search:

Futibatinib Ivosidenib Infigratinib

Pemigatinib 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one INCB-054828 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)- IBI-375 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one 2H8]-Pemigatinib INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic INCB 54828 INCB54828 INCB-54828 Terbufos Impurity 14 (Ethion) Pemigatinib, 10 mM in DMSO 1513857-77-6 1513857-77-7 C24H27F2N5O4 APIS