Indoline
- CAS No.
- 496-15-1
- Chemical Name:
- Indoline
- Synonyms
- Dihydroindole;2,3-DIHYDRO-1H-INDOLE;2,3-DIHYDROINDOLE;1H-Indole, 2,3-dihydro-;IDN;NDOLINE;INDOLINE;1-Azaindan;1H-Indoline;Indoline>
- CBNumber:
- CB5485525
- Molecular Formula:
- C8H9N
- Molecular Weight:
- 119.16
- MOL File:
- 496-15-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/26 10:39:04
| Melting point | -21 °C |
|---|---|
| Boiling point | 220-221 °C (lit.) |
| Density | 1.063 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 199 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 5g/l; lnsoluble in water, soluble in alcohol and oils. Poorly soluble in Propylene glycol. |
| form | liquid (clear) |
| pka | 5.20±0.20(Predicted) |
| color | clear dark brown |
| Odor | a mild, delicate, but extremely tenacious floral odor |
| Water Solubility | 5 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| BRN | 111915 |
| CAS DataBase Reference | 496-15-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Indole, 2,3-dihydro-(496-15-1) |
| EPA Substance Registry System | 1H-Indole, 2,3-dihydro- (496-15-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210e-P261-P280a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 23-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NL6906300 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339990 | |||||||||
| NFPA 704 |
|
Indoline price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I5605 | Indoline ReagentPlus?, 99% | 496-15-1 | 25G | ₹3539.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I5605 | Indoline ReagentPlus?, 99% | 496-15-1 | 100G | ₹12124 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0033 | Indoline min. 98.0 % | 496-15-1 | 25ML | ₹3900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0033 | Indoline min. 98.0 % | 496-15-1 | 250ML | ₹13700 | 2022-05-26 | Buy |
Indoline Chemical Properties,Uses,Production
Chemical Properties
?2,3-Dihydroindole [496-15-1], indoline C8H9N, Mr 119.16, bp 229 – 230 ℃(101.3 kPa), is a colorless liquid, which is volatile in steam and soluble in diethyl ether, acetone, and benzene, but only slightly soluble in water. Indoline is obtained by hydrogenation of indole or by catalytic cyclodehydration of 2-(2-aminophenyl)ethanol. A range of pharmaceuticals, as well as fungicides and bactericides, can be produced from indoline.
Uses
As an indole derivative, Indoline can be used in the preparation of various medicinal compounds such as potential α1-adrenoceptor (α1-AR) antagonists.
Synthesis Reference(s)
Journal of the American Chemical Society, 96, p. 7812, 1974 DOI: 10.1021/ja00832a035
Synthetic Communications, 13, p. 489, 1983 DOI: 10.1080/00397918308081827
Synthesis
Indolene is manufactured from (theoretically) 2 Mol. Indole plus 1 Mol. Hydroxycitronellal by condensation under heating. The proportions may vary slightly, and it is common practice to add Diethyl phthalate to the mixture prior to heating, so that the condensation product is somewhat protected against local overheating, and the finished product becomes light of color and fairly pourable at room temperature.
Indoline Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sunlight Active Drug Ingredients Pvt ltd | +91 9705345345 | Telangana, India | 28 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Thakkar Group of Industries | +91-9167974164 | Maharashtra, India | 8 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Sumar Biotech Llp | 08068970642Ext 388 | Gujarat, India | 12 | 58 | Inquiry |
| Nilkanth Organics | 08048980314 | Mumbai, India | 118 | 58 | Inquiry |
| Lambda Therapeutic Research Limited | 08068442251Ext 309 | Ahmedabad, India | 7 | 58 | Inquiry |
| Valiant Pharmatech | 08047649196 | Hyderabad, India | 16 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Sunlight Active Drug Ingredients Pvt ltd | 58 |
| JSK Chemicals | 58 |
| Thakkar Group of Industries | 58 |
| OCEAN TRADING CORPORATION | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Sumar Biotech Llp | 58 |
| Nilkanth Organics | 58 |
| Lambda Therapeutic Research Limited | 58 |
| Valiant Pharmatech | 58 |