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JC-1

JC-1 Structure
CAS No.
3520-43-2
Chemical Name:
JC-1
Synonyms
JC-1;JC-1, >95%;JC-1 jodide;CBIC2, >95%;ChemicalbookCBIC2,>95%;JC-1[5,5,6,6-Tetrachloro-1,1,3,3;-tetrachloroimidacarbocyanine iodide;inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor;5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA;1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide
CBNumber:
CB5497188
Molecular Formula:
C25H27Cl4N4.I
Molecular Weight:
652.228
MOL File:
3520-43-2.mol
Modify Date:
2023/6/8 9:02:15
Request For Quotation

JC-1 Properties

Melting point 275–278 ℃
storage temp. room temp
solubility Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide
form crystals
color Deep red
λmax 514nm
Stability Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO or distilled water may be stored at 4°C for up to 1 year. DO NOT FREEZE/THAW SOLUTIONS. Sterilize solutions only by filtration, not by autoclaving
Biological Applications Detectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity
Major Application Langmuir-Blodgett films; lasing systems; nonlinear optical materials; photographic materials1,
InChIKey FYNNIUVBDKICAX-UHFFFAOYSA-M

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H410-H335-H319-H302
Precautionary statements  P273-P391-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
WGK Germany  3
F  10-21
NFPA 704
0
2 0

JC-1 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T4069 JC-1 solid 3520-43-2 5MG ₹68652.15 2022-06-14 Buy
Product number Packaging Price Buy
T4069 5MG ₹68652.15 Buy

JC-1 Chemical Properties,Uses,Production

Description

JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis. It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry. A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers). JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.

Uses

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

JC-1 Suppliers

Global( 91)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Jiangxi Lotchem Co.,Ltd. +8615270827708 CHINA 338 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Alfa Chemistry +1-5166625404 United States 21317 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Jiangxi Lotchem Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Alfa Chemistry 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Jilin Chinese Academy of Sciences-yanshen Technology 58

JC-1 Spectrum

JC-1(3520-43-2)1HNMR

3520-43-2(JC-1)Related Search:

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JC-1 CHLORIDE 1,3-DIMETHYLIMIDAZOLIUM IODIDE 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE 5,6-Dichloro-1-ethyl-2-methylbenzimidazole JC-1
1-ETHYL-3-METHYLIMIDAZOLIUM IODIDE 5,6-DICHLOROBENZIMIDAZOLE 5-CHLORO-1,2-DIMETHYLBENZIMIDAZOLE 1H-Benzimidazole,2-ethenyl-(9CI) N-ETHYL-5,6-DICHLOROBENZIMIDAZOLE
N,N-Dimethyl-o-phenylenediamine dihydrochloride 1,2,3-TRIMETHYLIMIDAZOLIUM IODIDE 5,6-DICHLORO-1-ETHYL-3-OCTADECYL-2-[3-(5,6-DICHLORO-1-ETHYL-3-OCTADECYL-1,3-DIHYDRO-2H-BENZIMIDAZOLIUM IODIDE
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5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide JC-1 JC-1,5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3) JC-1 jodide 1h-benzimidazolium, 5,6-dichloro-2[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2h-benzimidazol-2-ylidene)-1-propenyl]-1,3-diethyl-, Iodide 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethylbenzimidazolium Iodide Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethyl-, Iodide Benzimidazolocarbocyanine Iodide, 5,50,6,60-tetrachloro-1,10,3,30-tetraethyl- Imidacarbocyanine Iodide, 1,10,3,30-tetraethyl-5,50,6,60-tetrachloro- 1,10,3,30-tetraethyl-5,50,6,60-tetrachlorobenzimidazolocarbocyanine Iodide 1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide 5,50,6,60-tetrachloro-1,10,3,30-tetraethylbenzimidazolocarbocyanine Iodide 5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide (47729-63-5) 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide CBIC2, >95% JC-1, >95% JC-1 [5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] *CAS#: 3520-43-2* 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole -tetrachloroimidacarbocyanine iodide ChemicalbookCBIC2,>95% JC-1[5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] JC-1[5,5,6,6-Tetrachloro-1,1,3,3 inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor 3520-43-2 Cyanine