Physalaemin

Physalaemin Structure
CAS No.
2507-24-6
Chemical Name:
Physalaemin
Synonyms
FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
CBNumber:
CB5674482
Molecular Formula:
C58H84N14O16S
Molecular Weight:
1265.44
MOL File:
2507-24-6.mol
Modify Date:
2023/7/17 20:29:20

Physalaemin Properties

storage temp. −20°C
solubility Soluble in DMSO
InChIKey SHSUJLMLURFKID-PYQGFWJGNA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

Physalaemin Chemical Properties,Uses,Production

Description

Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

Uses

Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

References

[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

Physalaemin Preparation Products And Raw materials

Raw materials

Preparation Products

Physalaemin Suppliers

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FI 6422 Physalemin(7CI,8CI,9CI) PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 PHYSALAEMIN PHYSALAEMIN ACOH 3H2O PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2 PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2 L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2 Physalaemine Physalemin Physalaemin, ≥97% (HPLC) L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl- 2507-24-6 C58H84N14O16S1 C58H84N14O16S Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Tachykinins Peptide