4-TRIMETHYLSILYL-3-BUTYN-2-OL
- CAS No.
- 6999-19-5
- Chemical Name:
- 4-TRIMETHYLSILYL-3-BUTYN-2-OL
- Synonyms
- DK369;TIMTEC-BB SBB009027;4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-(Trimethysilyl)-3-butyn-2-ol;1-TRIMETHYLSILYLBUT-1-YNE-3-OL;4-Trimethylsilyl-3-butynol, t;4-(triMethylsilyl)but-3-yn-2-ol;3-Butyn-2-ol, 4-(trimethylsilyl)-;(+/-) 4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-TRIMETHYLSILYL-3-BUTYN-2-OL (+/-)
- CBNumber:
- CB5676325
- Molecular Formula:
- C7H14OSi
- Molecular Weight:
- 142.27
- MOL File:
- 6999-19-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Boiling point | 76 °C |
|---|---|
| Density | 0.847 g/mL at 25 °C |
| refractive index |
n |
| Flash point | 143 °F |
| storage temp. | 2-8°C |
| solubility | highly soluble in all standard organic solvents (hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially soluble in water. |
| pka | 13.78±0.20(Predicted) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| Specific Gravity | 0.846 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1923632 |
| CAS DataBase Reference | 6999-19-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
4-TRIMETHYLSILYL-3-BUTYN-2-OL price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 5G | ₹6213.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 25G | ₹27203.23 | 2022-06-14 | Buy |
| ALFA India | ALF-L14815-14 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 25g | ₹16972 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1926 | 4-Trimethylsilyl-3-butyn-2-ol min. 97.0 % | 6999-19-5 | 5G | ₹5500 | 2022-05-26 | Buy |
| ALFA India | ALF-L14815-06 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 5g | ₹5500 | 2022-05-26 | Buy |
4-TRIMETHYLSILYL-3-BUTYN-2-OL Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Physical properties
bp 83–85°C (13 mmHg).
Uses
More recently, Mulzer has reported use of the corresponding
allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis
of the C13–C18 fragment of branimycin (eq 2).
Preparation
racemic 4-trimethylsilyl-3-butyn-2-ol can
be prepared by deprotonation with strong bases (BuLi, LDA,
Grignards reagents) of trimethylsilylacetylene followed
by addition to acetaldehyde.Deprotonation of 3-butyn-2-
ol followed by quenching with excess trimethylsilyl chloride
followed by concomitant hydrolysis of the trimethylsilyl ether
is generally the most straightforward route.Enzymatic reduction
of 4-TMS-3-butyn-2-one has also been used to prepare the
reagent using alcohol dehydrogenase.
Preparation of nonracemic 4-TMS-3-butyn-2-ol has been
accomplished by asymmetric addition of dimethylzinc to
acetaldehyde promoted by TADDOL or addition of a
trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal
elimination of the sulfoxide.Asymmetric reduction of 4-
TMS-3-butyn-2-one using stoichiometric reducing reagents,
catalytic transfer hydrodrogenation,and enzymatic reduction
with isolated protein or whole cells afford the 4-TMS-3-butyn-
2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method
of choice for the large-scale preparation.
4-TRIMETHYLSILYL-3-BUTYN-2-OL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19805 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 3315 | 55 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30231 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| Alfa Chemistry | United States | 2344 | 58 | Inquiry | |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
| CD Chemical Group Limited | +8615986615575 | China | 20342 | 58 | Inquiry |
| Bio Connect Life Sciences | United States | 261 | 58 | Inquiry |
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