ChemicalBook > Product Catalog >API >Circulatory system drugs >Peripheral vasodilators >Phentolamine mesilate
Phentolamine mesilate
- CAS No.
- 65-28-1
- Chemical Name:
- Phentolamine mesilate
- Synonyms
- PHENTOLAMINE MESYLATE;VASOMAX;REGITIN;PhentoL;FE202158;FE 202158;amine MesyL;REGITIN MESYLATE;regitinemesylate;Phentolaminmesilat
- CBNumber:
- CB5708736
- Molecular Formula:
- C18H23N3O4S
- Molecular Weight:
- 377.46
- MOL File:
- 65-28-1.mol
- Modify Date:
- 2024/7/7 20:48:41
| Melting point | 180-182 °C(lit.) |
|---|---|
| Density | 1.2256 (rough estimate) |
| refractive index | 1.6320 (estimate) |
| storage temp. | 2-8°C |
| solubility | ethanol: 26 mg/mL |
| form | powder |
| color | white to off-white |
| Water Solubility | 50 mg/mL |
| Merck | 14,7264 |
| Stability | Aq. Solutions Cannot be Stored |
| InChI | InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4) |
| InChIKey | OGIYDFVHFQEFKQ-UHFFFAOYSA-N |
| SMILES | N(CC1=NCCN1)(C1C=CC(C)=CC=1)C1C=CC=C(O)C=1.S(=O)(=O)(O)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SL5430000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332900 | |||||||||
| Toxicity | LDLo scu-rat: 275 mg/kg NIIRDN 6,667,82 | |||||||||
| NFPA 704 |
|
Phentolamine mesilate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P7561 | Phentolamine methanesulfonate salt ≥98% (TLC), powder | 65-28-1 | 100MG | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1403 | Phentolamine Mesylate Pharmaceutical Secondary Standard; Certified Reference Material | 65-28-1 | 1G | ₹10002.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7561 | Phentolamine methanesulfonate salt ≥98% (TLC), powder | 65-28-1 | 500MG | ₹38915.88 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P1985 | Phentolamine Mesylate | 65-28-1 | 100MG | ₹2700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P1985 | Phentolamine Mesylate | 65-28-1 | 1G | ₹4100 | 2022-05-26 | Buy |
Phentolamine mesilate Chemical Properties,Uses,Production
Chemical Properties
Phentolamine mesylate is a white, odourless powder which is soluble in water and alcohol.
Uses
Phentolamine mesilate is an adrenergic blocking agent and antihypertensive. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
General Description
Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Safety Profile
Poison by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Mode of action
Phentolamine Mesylate is the mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.
Phentolamine mesilate Preparation Products And Raw materials
Global( 398)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| MYLAN LABORATORIES LIMITED | 040 -3086 6666 | New Delhi, India | 68 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
65-28-1(Phentolamine mesilate)Related Search:
REGITIN
REGITIN MESYLATE
PHENTOLAMINE MESILATE
PHENTOLAMINE METHANESULFONATE
PHENTOLAMINE METHANESULFONATE SALT
VASOMAX
m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonomethanesulfonate(sal
phentolaminemethanesulphonate
3-[4,5-Dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)-amino]phenol methanesulfonate
Phentolamine·methanesulfonic acid
Regitine methanesulfonate
Phentolamine mesilat
Phentolamine Mesylate (200 mg)
2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Methanesulfonate
Phentolamine Methanesulfonate
3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol, methanesulfonate (1:1)
Phentolamine mesilate for system suitability
Phentolamine mesylate, >=99%
Phentolamine mesilate(Regitine)
regitinemesylate
regitinmethanesulphonate
2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE, METHANESULFONATE
2-(N-[M-HYDROXYPHENYL]-P-TOLUIDINOMETHYL)IMIDAZOLINE METHANESULFONATE SALT
2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLIN METHANESULFONATE SALT
3-[[(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL](4-METHYLPHENYL)-AMINO]PHENOL MESYLATE
3-[n-(2-imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate
PHENOL, 3-(((4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL)(4-METHYLPHENYL)AMINO)-, MONOMETHANESULFONATE (SALT)
PhentolamineMesylateCp2000/Usp26Gmp
Phentolaminemethanesulfonate,99%
PHENTOLAMINEMESYLATE,USP
PHENTOLAMINE METHANESULFONATE (PHENTOLAMINE MESYLATE)
amine MesyL
PhentoL
Phentolamine mesylate, ≥98.0%(TLC)
Phentolamine methanesulfonate salt, 98%, a nonselective alpha-adrenergic antagonist
Phentolamine mesilate CRS
PhentolamineMesylate>
Phentolamine for system suitability CRS
Phentolaminmesilat
Phentolamine mesilate USP/EP/BP
Phentolamine Mesylate (1530004)
FE 202158
FE202158
PHENTOLAMINE MESYLATE
3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonate
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (benzylpenicillin)
65-28-1
C17H19N3OCH4O3SC18H23
C17H19N3OCH3SO3H
C17H19N3OCH4O3SC18H23N3O4S
C17H19N3O.CH4O3S
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