LE 300
![LE 300 Structure](CAS/GIF/274694-98-3.gif)
- CAS No.
- 274694-98-3
- Chemical Name:
- LE 300
- Synonyms
- LE 300;6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine;6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE;7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE;5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
- CBNumber:
- CB5714645
- Molecular Formula:
- C20H22N2
- Molecular Weight:
- 290.4
- MOL File:
- 274694-98-3.mol
- Modify Date:
- 2023/6/30 15:45:59
LE 300 Chemical Properties,Uses,Production
Description
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
Uses
LE 300 is a potent and selective dopamine receptor antagonist.
Biological Activity
Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .
LE 300 Preparation Products And Raw materials
Raw materials
Preparation Products
LE 300 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | China | 2992 | 58 | Inquiry |
TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9708 | 58 | Inquiry |
BOC Sciences | USA | 0 | 65 | Inquiry | |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4455 | 58 | Inquiry |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | China | 5595 | 58 | Inquiry |
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