4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy
![4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Structure](CAS/GIF/2226-96-2.gif)
- CAS No.
- 2226-96-2
- Chemical Name:
- 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy
- Synonyms
- TEMPOL;4-OH-TEMPO;4-HYDROXY-TEMPO;Inhibitor 701;ZJ-701;TMPN;HYDROXY-TEMPO;Polymerization inhibitor 701;Tetramethylpiperidinol N-oxyl;4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl
- CBNumber:
- CB5782374
- Molecular Formula:
- C9H18NO2*
- Molecular Weight:
- 172.24
- MOL File:
- 2226-96-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/29 17:54:30
Melting point | 69-71 °C(lit.) |
---|---|
Boiling point | 302.58°C (rough estimate) |
Density | 1.0402 (rough estimate) |
vapor pressure | 0.025Pa at 20℃ |
refractive index | 1.4350 (estimate) |
Flash point | 146°(295°F) |
storage temp. | 2-8°C |
solubility | 1670g/l |
form | Crystals or Crystalline Powder |
pka | 5.07[at 20 ℃] |
color | Orange |
PH | 8.2 (20g/l, H2O, 20℃) |
Water Solubility | soluble |
Merck | 14,9141 |
BRN | 1422990 |
Stability | Stable. Incompatible with strong oxidizing agents. |
InChIKey | FAPCFNWEPHTUQK-UHFFFAOYSA-N |
LogP | 0.56 at 25℃ |
CAS DataBase Reference | 2226-96-2(CAS DataBase Reference) |
NIST Chemistry Reference | 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-(2226-96-2) |
EPA Substance Registry System | 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl- (2226-96-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H318 | |||||||||
Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P501 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38-36/38 | |||||||||
Safety Statements | 26-36-37/39-36/37/39-27 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | TN8991000 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29333999 | |||||||||
Toxicity | LD50 oral in rat: 1053mg/kg | |||||||||
NFPA 704 |
|
4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 176141 | 4-Hydroxy-TEMPO 97% | 2226-96-2 | 1G | ₹1890 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 176141 | 4-Hydroxy-TEMPO 97% | 2226-96-2 | 5G | ₹5310 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 581500 | TEMPOL - CAS 2226-96-2 - Calbiochem A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. | 2226-96-2 | 500MG | ₹10550.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 176141 | 4-Hydroxy-TEMPO 97% | 2226-96-2 | 25G | ₹18050 | 2022-06-14 | Buy |
TCI Chemicals (India) | H0865 | 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical min. 98.0 % | 2226-96-2 | 5G | ₹4200 | 2022-05-26 | Buy |
4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Chemical Properties,Uses,Production
Description
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.
Chemical Properties
solid
Uses
A free radical scavenger
Application
In biochemical research, 4-hydroxy-TEMPO has been investigated as an agent for limiting reactive oxygen species. It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.4-Hydroxy-TEMPO, along with related nitroxides, are being studied for their potential antioxidant properties.On an industrial-scale 4-hydroxy-TEMPO is often present as a structural element in hindered amine light stabilizers, which are commonly used stabilizers in plastics, it is also used as a polymerisation inhibitor, particularly during the purification of styrene.
General Description
4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.
Biological Activity
Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.
4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
SAGAR LIFE SCIENCES PVT LTD | +91-8770359041 +91-8770359041 | Gujarat, India | 79 | 58 | Inquiry |
Cefa-Cilinas Biotics Pvt Ltd | +91-7875033155 +91-8080701561 | Maharashtra, India | 121 | 58 | Inquiry |
SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
C. J. Chemicals Private Limited | 08048372638Ext 579 | Hyderabad, India | 24 | 58 | Inquiry |
Supplier | Advantage |
---|---|
SAGAR LIFE SCIENCES PVT LTD | 58 |
Cefa-Cilinas Biotics Pvt Ltd | 58 |
SL Drugs and Pharmaceuticals Pvt. Ltd. | 50 |
CHEMSWORTH | 30 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
Otto Chemie Pvt. Ltd. | 58 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
Alfa Aesar | 58 |
C. J. Chemicals Private Limited | 58 |
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