Avermectin B1a
- CAS No.
- 65195-55-3
- Chemical Name:
- Avermectin B1a
- Synonyms
- Abamectina;Avamectin B1a;AbaMectin B1a;C-076B1a;ABERMECTINS;Abamectinum;avermectin b1a;Antibiotic C-076B1a;Abamectine [french];Abamectinum [latin]
- CBNumber:
- CB5854808
- Molecular Formula:
- C48H72O14
- Molecular Weight:
- 873.09
- MOL File:
- 65195-55-3.mol
- Modify Date:
- 2024/8/4 16:55:17
| Boiling point | 940.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥143.4 mg/mL in DMSO; ≥11.86 mg/mL in EtOH with ultrasonic; insoluble in H2O |
| form | Powder |
| pka | 12.42±0.70(Predicted) |
| color | White to light yellow |
| Stability | Hygroscopic |
| EPA Substance Registry System | Avermectin B1a (65195-55-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS09,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H410-H300-H361d-H372 | |||||||||
| Precautionary statements | P273-P391-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| RIDADR | 2588 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84 | |||||||||
| NFPA 704 |
|
Avermectin B1a Chemical Properties,Uses,Production
Description
Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits binding of the glycine receptor antagonist strychnine to membranes and the solubilized receptor from rat spinal cord (Kis = 1.3 and 3.6 μM, respectively). Formulations containing avermectin B1a (>80%) and avermectin B1b (~20%; ) are used in insecticides and veterinary anthelmintic formulas as abamectin .
Uses
Avermectin B1a is the major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 25-position. In vitro and in vivo studies have shown that this analogue is the more potent analogue in the commercial product.
Hazard
A poison by ingestion. Moderately toxic by skin contact.
Safety Profile
A poison by ingestion.Moderately toxic by skin contact. When heated todecomposition it emits acrid smoke and irritating fumes.
Avermectin B1a Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3878 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | China | 2989 | 55 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
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