Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- CAS No.
- 71827-03-7
- Chemical Name:
- Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- Synonyms
- Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin 2-epimer (Dihydro Avermectin B1a);Ivermectin B1a-D2Q: What is Ivermectin B1a-D2 Q: What is the CAS Number of Ivermectin B1a-D2
- CBNumber:
- CB9928288
- Molecular Formula:
- C48H74O14
- Molecular Weight:
- 875.09
- MOL File:
- 71827-03-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:08
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties,Uses,Production
Description
Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.
Definition
ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Molsyns Research | +91-9586858886 +91-9586858886 | Gujarat, India | 418 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | China | 39009 | 58 | Inquiry |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | China | 3635 | 55 | Inquiry |