Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
- CAS No.
- 70209-81-3
- Chemical Name:
- Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
- Synonyms
- Component B1b;Ivermectin B1b;IvermectinH2B1b;avermectin H2B1b;Dihydroavermectin B1b;22,23-Dihydroavermectin B1b;22,23- dihydroavermectin B1b (Ivermectin B1b);22,23-Dihydro-34-nor-5-O-demethylavermectin A1a;DihydroaverMectin B1b, 22,23-DihydroaverMectin B1b;22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)-25-isopropylavermectin A1a
- CBNumber:
- CB2918291
- Molecular Formula:
- C47H72O14
- Molecular Weight:
- 861.07
- MOL File:
- 70209-81-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
| Boiling point | 934.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble |
| form | A solid |
| pka | 12.42±0.70(Predicted) |
| Stability | Temperature sensitive |
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Chemical Properties,Uses,Production
Uses
Ivermectin B1b (dihydroavermectin B1b) is the minor component (<20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro, the B1b (25-iso-propyl) analogue is slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis, and also a more sensitive probe for ivermectin resistance.
Definition
ChEBI: A macrocyclic lactone that is avermectin B1b in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the minor component of ivermectin.
brand name
Stromectol (Merck).
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29821 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | China | 3635 | 55 | Inquiry |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | China | 56247 | 58 | Inquiry |