Lasalocid
- CAS No.
- 25999-31-9
- Chemical Name:
- Lasalocid
- Synonyms
- Lasalocid;Aids003766;Lasalocid A;Aids-003766;Ionophore X-537A;Antibiotic X-537A;X 537A, Lasalocid A;Nsc243046 (sodium salt);25999-20-6 (Sodium salt);Lasalocid, 10 mM in DMSO
- CBNumber:
- CB5875179
- Molecular Formula:
- C34H54O8
- Molecular Weight:
- 590.79
- MOL File:
- 25999-31-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/19 23:02:33
| Melting point | 110-114°; mp 100-109° (unsharp) |
|---|---|
| alpha | D25 -7.55° (methanol) |
| Boiling point | 735.7±60.0 °C(Predicted) |
| Density | 1.119±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Acetonitrile,(Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 3.15±0.39(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice (mg/kg): 40 i.p. (Berger); also reported as LD50 in mice (mg/kg): 146 orally, 64 i.p., J. W. Westley, "Antibiotics (Polyether)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 3 (Interscience, New York, 3rd ed., 1978) p 61 |
|---|
Lasalocid Chemical Properties,Uses,Production
Description
Lasalocid is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. Lasalocid cytotoxicity targets cell metabolism, demonstrating EC50 values in the range of 7-
Uses
Lasalocid is a polyether ionophore with potent antibacterial activity isolated from Streptomyces lasaliensis, first reported in 1951. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine.
brand name
Avatec [as sodium] [Veterinary] (Hoffmann-LaRoche); Bovatec [as sodium] [Veterinary] (Hoffmann-LaRoche).
General Description
Lasalocid is one of the polyether ionophore antibiotics and was found in the culture broth of Streptomyces lasaliensis by Hoffmann-La Roche in 195. It shows activity against gram-positive bacteria, including Mycobacterium and Streptomyces, and also against anaerobic bacteria, but it has no activity against gramnegative bacteria or fungi. Lasalocid also shows strong anticoccidial activity, and it stimulates propionic acid formation in the rumen. It is used for prophylaxis and for therapy of coccidial infections in poultry and as a feed additive for growth promotion in cattle.
Lasalocid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32202 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15393 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | China | 33338 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40066 | 58 | Inquiry |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | China | 43416 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131957 | 58 | Inquiry |
| Jiangxi Jianglan Pure Biological Reagent Co., Ltd. | 021-54720761 | CHINA | 6134 | 58 | Inquiry |
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