6-pentadecylsalicylic acid
- CAS No.
- 16611-84-0
- Chemical Name:
- 6-pentadecylsalicylic acid
- Synonyms
- Anachardic acid;NSC 623096;NSC 333857;NSC 229596;22:0-Anacardic acid;Anacardic Acid 15:0;(15:0)-Anacardic acid;Cyclogallipharic acid;PENTADECYLSALICYLICACID;Hydrogenated anacardic acid
- CBNumber:
- CB01364624
- Molecular Formula:
- C22H36O3
- Molecular Weight:
- 348.52
- MOL File:
- 16611-84-0.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 90-91℃ |
|---|---|
| Boiling point | 474.8±33.0 °C(Predicted) |
| Density | 1.002 |
| storage temp. | -20°C |
| solubility | DMSO: ≥20mg/mL |
| form | White solid |
| pka | 3.08±0.30(Predicted) |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N |
| LogP | 9.960 (est) |
6-pentadecylsalicylic acid price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A7236 | Anacardic acid | 16611-84-0 | 5MG | ₹15891.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A7236 | Anacardic acid | 16611-84-0 | 25MG | ₹63488.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 172050 | Anacardic Acid - CAS 16611-84-0 - Calbiochem The Anacardic Acid, also referenced under CAS 16611-84-0, modulates the biological activity of Anacardic. This small molecule/inhibitor is primarily u | 16611-84-0 | 10MG | ₹15469.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 05506 | (15:0)-Anacardic acid analytical standard | 16611-84-0 | 10MG | ₹31132.7 | 2022-06-14 | Buy |
6-pentadecylsalicylic acid Chemical Properties,Uses,Production
Description
Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-
Uses
Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC50 values of 8.5 and 5 μM, respectively. At 25 μmol/L, anacardic acid suppresses NF-κB activation, inhibits IκB-α phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.[Cayman Chemical]
General Description
A cell-permeable ginkgolic acid (Cat. No. 345887) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 2.2 μM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation. Both anacardic acid and ginkgolic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although anacardic acid is shown to inhibit p300 (Cat. No. 506200) and PCAF (Cat. No. 124026) histone acetyltransferase activities in cell-free acetylase assays (by 82% and 86%, respectively, at 10 μM). Also reported to inhibit the activity of prostaglandin synthase, tyrosinase, and lipoxygenase, as well as to enhance Aurora kinase A (Cat. No. 481413), but not Aurora kinase B, autophosphorylation and kinase activity by inducing conformation change and enhancing ATP binding.
6-pentadecylsalicylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12962 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | China | 1478 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
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