flumethiazide
![flumethiazide Structure](CAS/GIF/148-56-1.gif)
- CAS No.
- 148-56-1
- Chemical Name:
- flumethiazide
- Synonyms
- Ademol;Routrax;Fludemil;NSC44626;NSC 44626;NSC-44626;flumethiazide;Trifluoromethylthiazide;6-Trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiazine 1,1-dioxide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
- CBNumber:
- CB5905531
- Molecular Formula:
- C8H6F3N3O4S2
- Molecular Weight:
- 329.278
- MOL File:
- 148-56-1.mol
- Modify Date:
- 2023/5/4 17:34:33
flumethiazide Chemical Properties,Uses,Production
Originator
Ademol,Squibb,US,1959
Manufacturing Process
Chilled 3-trifluoromethylaniline (32.2 g) is added dropwise over a 45-minute
period to 150 ml of chlorosulfonic acid with stirring and cooling. The ice bath
is removed and 140 g of sodium chloride is added over 3 hours. The mixture
is heated on a water bath for 30 minutes, then gradually up to 160°C over 6
hours. The cooled reaction mixture is diluted with 500 ml of an ice water
slurry and taken into ether. The ether is dried and evaporated to leave 5-
trifluoromethylamine-2,4-disulfonyl chloride.
The crude residue is heated on the steam bath for 1 hour with 75 ml of
concentrated ammonium hydroxide. Cooling and filtration gives 2,4-
disulfamyl-5-trifluoromethylaniline, MP 241°C to 243°C.
This intermediate is treated with an excess of 98% formic acid at steam bath
temperature for 3 hours. Evaporation and dilution with water gives 7-sulfamyl-
6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide, MP 304°C to 308°C.
Therapeutic Function
Carbonic anhydrase inhibitor
flumethiazide Preparation Products And Raw materials
flumethiazide Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9968 | 58 | Inquiry |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Lanospharma Laboratories Co.,Ltd | 56 |
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 58 |