chlornaphazine
- CAS No.
- 494-03-1
- Chemical Name:
- chlornaphazine
- Synonyms
- R48;Erysan;CB 1048;Cloronaftina;chlornaphazin;chlornaphazine;DICHLOROETHYL-BETA-NAPHTHYLAMINE;bis(2-chloroethyl)-(2-naphthyl)amine;N,N-Bis(2-chloroethyl)-2-naphtylamine;DI-(2-CHLOROETHYL)-BETA-NAPHTHYLAMINE
- CBNumber:
- CB5916238
- Molecular Formula:
- C14H15Cl2N
- Molecular Weight:
- 268.185
- MOL File:
- 494-03-1.mol
- Modify Date:
- 2024/3/14 15:18:27
| Melting point | 54-56° |
|---|---|
| Boiling point | bp5 210° |
| Density | 1.2039 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| pka | 2.75±0.70(Predicted) |
| color | Platelets from pet ether |
| IARC | 1 (Vol. 4, Sup 7, 100A) 2012 |
| EPA Substance Registry System | Chlornaphazine (494-03-1) |
chlornaphazine Chemical Properties,Uses,Production
Chemical Properties
Chlornaphazine is composed of clear, colorless plates or may be a brown solid.
World Health Organization (WHO)
The World Health Organization has no information further to the above regarding preparations containing chlornaphazine or to indicate that they are still commercially manufactured.
General Description
Colorless plates or brown solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
chlornaphazine reacts with nucleophiles .
Fire Hazard
Flash point data are not available for chlornaphazine , but chlornaphazine is probably combustible.
Safety Profile
Confirmed human carcinogenproducing bladder tumors. Human and experimentalcarcinogenic data. Moderately toxic by intraperitonealroute. When heated to decomposition it emits very toxicfumes of Cl- and NOx.
Potential Exposure
May be combustible and possibly explosive. Not produced or used commercially in the United States, Chlornaphazine has been used in other countries in the treatment of leukemia and related cancers. Currently, this drug does not have wide therapeutic usage.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Crystallise it from pet ether. At 15o it is soluble in EtOH (3.2%), Et2O (50%), Me2CO (84%) and *C6H6 (80%). [Beilstein 12 III 2996, 12 IV 3126.] CARCINOGENIC.
Incompatibilities
Keep away from oxidizers, nucleophiles, and nitromethanes. Amines may react violently with nitric acid; cellulose nitrate (of high surface area); 1-chloro-2,3-epoxypropane (exothermic reaction may occur). Incompatible with acids, acid halides; alcohols, aldehydes, alkylene oxides; anhydrides, cresols, caprolactam solution; epichlorohydrin, epoxides, isocyanates, glycols, peroxides, phenols. Contact with strong reducing agents may generate flammable hydrogen gas. May attack copper and copper alloys.
Waste Disposal
Disposal of unused product must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate protective equipment. For proper handling and disposal, always comply with federal, state, and local regulations.
chlornaphazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 23963 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| Portail Substances Chimiques | 10 20 0000 | France | 6027 | 58 | Inquiry |