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8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Structure
CAS No.
22316-55-8
Chemical Name:
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
Synonyms
Clofazin;Norclobazam;Einecs 244-909-2;Demethylclobazam;Desmethylclobazam;N-Demethylclobazam;Clobazam EP Impurity A;N-Desmethylclobazam (CRM);Clobazam Related Compound A;N-Desmethylclobazam solution
CBNumber:
CB5921872
Molecular Formula:
C15H11ClN2O2
Molecular Weight:
286.71
MOL File:
22316-55-8.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
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8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Properties

Melting point >239°C (dec.)
Boiling point 601.8±55.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
Flash point 2℃
storage temp. Controlled Substance, -20°C Freezer
solubility Acetonitrile (Soluble)
form A neat solid
pka 7.57±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332-H319
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338
Hazard Codes  F,Xn
Risk Statements  11-20/21/22-36
Safety Statements  16-36/37
RIDADR  UN 1648 3 / PGII
WGK Germany  2
Toxicity mouse,LD50,oral,> 2583mg/kg (2583mg/kg),United States Patent Document. Vol. #3760074,

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D-049 N-Desmethylclobazam solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 22316-55-8 1ML ₹19989.9 2022-06-14 Buy
Product number Packaging Price Buy
D-049 1ML ₹19989.9 Buy

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Chemical Properties,Uses,Production

Description

N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4. N-Desmethylclobazam positively modulates GABAA receptors (EC50s range from 98 to 151 μM, depending on subunit configuration). This product is intended for research and forensic applications.

Chemical Properties

Off-White Solid

Uses

The major metabolite of Clobazam Controlled substance (depressant).

General Description

A Certified Solution Standard for use in LC or GC applications from forensic and forensic toxicology analysis to urine drug testing. N-Desmethylclobazam, found in urine, serum, and plasma, is the pharmacologically active, major metabolite of clobazam.

8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Preparation Products And Raw materials

Raw materials

1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro- 5-chloro-N-phenylbenzene-1,2-diamine 5-CHLORO-2-NITRODIPHENYLAMINE ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate 4-Chloro-o-phenylenediamine
Triphenylbismuth MONOMETHYL MALONATE Diethyl malonate Aniline 4-Chloro-2-fluoronitrobenzene
Malonyl chloride 4-Chloro-2-nitroaniline
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8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Suppliers

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Chemicea Pharmaceuticals Pvt Ltd +91-918482849343 +91-8482849343 Mumbai, India 461 58 Inquiry
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Chemicea Pharmaceuticals Pvt Ltd 58
Varanous Labs Pvt Ltd 58
Aventus Labs 58
Vishrudh laboratories pvt ltd 58
Vijaya Pharma And Life Science 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
sgtlifesciences pvt ltd 58
Shaanxi Didu New Materials Co. Ltd 58
Aromsyn Co., Ltd. 58
7-Chloro-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione 8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione 7-Chloro-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione Desmethylclobazam Norclobazam 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 8-chloro-1-phenyl- Clofazin Demethylclobazam Einecs 244-909-2 N-Demethylclobazam 8-chloro-1-phenyl-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dione N-Desmethylclobazam solution 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione N-Desmethylclobazam (CRM) Clobazam EP Impurity A Clobazam Impurity 1（Clobazam EP Impurity A） N-Desmethyl Clobazam (100 μg/mL in Acetonitrile ) Clobazam EP Impurity A (N-Desmethylclobazam) N-DesmethylclobazamQ: What is N-Desmethylclobazam Q: What is the CAS Number of N-Desmethylclobazam Q: What is the storage condition of N-Desmethylclobazam Q: What are the applications of N-Desmethylclobazam Clobazam impurity A (Y0000241) Clobazam - Impurity A (Freebase) Clobazam Related Compound A Clobazam USP Related Compound A N-Desmethylclobazam (nor-Clobazam) 7-Chloro-5-phenyl-1,5-dihydro-3H-1,5-benzodiazepine-2,4-dione (Norclobazam) 22316-55-8 2316-55-8 Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals