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SIS3

SIS3 Structure
CAS No.
521984-48-5
Chemical Name:
SIS3
Synonyms
SIS3;CS-2236;SIS3 HCl;Caneritinib;SIS3 (SIS 3;SIS3 hydrochloride;SIS 3 HCL;SIS-3 HCL;Caneritinib(CI-1033);1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride;(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride
CBNumber:
CB5973013
Molecular Formula:
C28H27N3O3HCl
Molecular Weight:
0
MOL File:
521984-48-5.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

SIS3 Properties

Melting point >161°C (dec.)
storage temp. 2-8°C
solubility H2O: <2mg/mL
form powder
color yellow
InChIKey CDKIEBFIMCSCBB-CALJPSDSSA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

SIS3 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S0447 SIS3 ≥98% (HPLC), powder 521984-48-5 5MG ₹38959.18 2022-06-14 Buy
Product number Packaging Price Buy
S0447 5MG ₹38959.18 Buy

SIS3 Chemical Properties,Uses,Production

Uses

Sugar insensitive 3 (SIS3) has been used as smad3?inhibitor in various cells.

Biochem/physiol Actions

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.

SIS3 Preparation Products And Raw materials

Raw materials

Preparation Products

SIS3 Suppliers

Global( 85)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Henan Aochuang Chemical Co.,Ltd. +86-0371-63689365 +8618638391208 China 9425 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
Alfa Chemistry 58
InvivoChem 58
Henan Aochuang Chemical Co.,Ltd. 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58

SIS3 Spectrum

SIS3(521984-48-5)1HNMR

521984-48-5(SIS3)Related Search:

1H-Pyrrolo[2,3-b]pyridine, 2,3-dimethyl- 1H-Pyrrolo[2,3-b]pyridine,1,3-dimethyl- SIS3
SIS3 (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride 2-Propen-1-one,1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-,hydrochloride (1:1), (2E)- SIS3 hydrochloride SIS3 HCl 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride Caneritinib(CI-1033) SIS 3 HCL;SIS-3 HCL 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride Caneritinib CS-2236 SIS3 (SIS 3 (E)-1-[6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl]-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one Hydrochloride myofibroblast,inhibit,TGF-β1,TGF-beta/Smad,(E)SIS3,Smad3,(E)-SIS3,Transforming growth factor beta,fibroblasts,differentiation,(E) SIS3,phosphorylation,(E)-SIS-3,Inhibitor 521984-48-5 C28H27N3O3HCl