SIS3
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- ₹38959.18
- Product name: SIS3
- CAS: 521984-48-5
- MF: C28H27N3O3HCl
- MW: 0
- EINECS:
- MDL Number:MFCD09265258
- Synonyms:SIS3;(2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride;2-Propen-1-one,1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-,hydrochloride (1:1), (2E)-;SIS3 hydrochloride;SIS3 HCl;1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride;Caneritinib(CI-1033);SIS 3 HCL;SIS-3 HCL
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberS0447
- Product descriptionSIS3 ≥98% (HPLC), powder
- Packaging5MG
- Price₹38959.18
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S0447 | SIS3 ≥98% (HPLC), powder | 5MG | ₹38959.18 | 2022-06-14 | Buy |
Properties
Melting point :>161°C (dec.)
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :powder
color :yellow
InChIKey :CDKIEBFIMCSCBB-CALJPSDSSA-N
Safety Information
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Description
SIS3 hydrochloride is a specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-β1. Studies conducted on scleroderma fibroblasts indicate that SIS3 hydrochloride suppresses type I collagen up-regulation. In addition, SIS3 hydrochloride inhibits Smad-responsive p3TP promoter constructs activation. These studies suggest that SIS3 hydrochloride reduces DNA binding of Smad3 and that pretreatment with SIS3 hydrochloride decreases DNA binding by 50%. SIS3 hydrochloride also interferes with the interaction between contransfected Smad3 and Smad4. Furthermore, SIS3 hydrochloride reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of α-SMA in these fibroblasts.More related product prices
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