2-Maleimido acetic acid
- CAS No.
- 25021-08-3
- Chemical Name:
- 2-Maleimido acetic acid
- Synonyms
- 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid;NSC 266055;N-Maleoylglycine;N-MaleiMidoglycine;N,N-maleoyl-glycine;MALEIMIDOACETIC ACID;2-maleimide acetic acid;2-MALEIMIDO ACETIC ACID;N-(CarboxyMethyl)MaleiMide;2-MALEIMIDO ACETIC ACID 97%
- CBNumber:
- CB61118111
- Molecular Formula:
- C6H5NO4
- Molecular Weight:
- 155.11
- MOL File:
- 25021-08-3.mol
- Modify Date:
- 2023/10/23 9:13:29
| Melting point | 114 °C(Solv: chloroform (67-66-3)) |
|---|---|
| Boiling point | 376.7±25.0 °C(Predicted) |
| Density | 1.578±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in DMSO, Methanol |
| form | powder to crystal |
| pka | 3.31±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C6H5NO4/c8-4-1-2-5(9)7(4)3-6(10)11/h1-2H,3H2,(H,10,11) |
| InChIKey | GBKPNGVKZQBPCZ-UHFFFAOYSA-N |
| SMILES | N1(CC(O)=O)C(=O)C=CC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2925.19.4200 | |||||||||
| NFPA 704 |
|
2-Maleimido acetic acid price More Price(2)
2-Maleimido acetic acid Chemical Properties,Uses,Production
Chemical Properties
White to Almost white powder to crystal or Pale Yellow Solid.
Uses
Maleimidoacetic Acid (CAS# 25021-08-3) is a heterocyclic organic compound that has a variety of uses in organic synthesis. It contains both a maleimide and carboxylic acid functional group, making it a versatile reagent for coupling reactions with amine-containing compounds.
Application
2-Maleimido acetic acid is a maleimide-containing ligand that could be used to produce the cisplatin-based Pt(IV) complexes (OC-6-44)-diamminedichlorido(ethanolato)(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV) and (OC-6-44)-acetatodiamminedichlorido(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV). The Pt(IV) complexes are considered to act as antitumor prodrugs and their in vivo activity can be improved by exploiting drug targeting and delivery strategies[1]. In this case, conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition.
References
[1] Gabano E, et al. Conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition. Inorganica Chimica Acta, 2019; 488: 195-200.
2-Maleimido acetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | CHINA | 272 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9326 | 58 | Inquiry |
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