Niclosamide

Niclosamide Properties

Melting point	225-230°
Boiling point	424.5±45.0 °C(Predicted)
Density	1.6646 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	acetone: methanol: soluble50mg/mL (methanol:acetone (1:1))
form	Pale yellow solid
pka	7.45±0.43(Predicted)
color	Yellow
Water Solubility	13.32mg/L(25 ºC)
BRN	2820605
BCS Class	4
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	RJMUSRYZPJIFPJ-UHFFFAOYSA-N
CAS DataBase Reference	50-65-7(CAS DataBase Reference)
EPA Substance Registry System	Niclosamide (50-65-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H400
Precautionary statements	P273-P391-P501
Risk Statements	50
Safety Statements	29
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	VN8400000
HS Code	29242990
Toxicity	LD50 oral in rat: 2500mg/kg

Niclosamide price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N3510	Niclosamide	50-65-7	50G	₹11961.63	2022-06-14	Buy
Sigma-Aldrich(India)	N3510	Niclosamide	50-65-7	250G	₹30851.25	2022-06-14	Buy
Sigma-Aldrich(India)	481909	Niclosamide - CAS 50-65-7 - Calbiochem A salicylanilide anthelmintic drug that acts as a potent and selective Stat3- and Wnt-signaling pathway inhibitor.	50-65-7	1G	₹4630.01	2022-06-14	Buy
ottokemi	N 0636	Niclosamide 98%	50-65-7	50gm	₹10809	2022-05-26	Buy
ottokemi	N 0636	Niclosamide 98%	50-65-7	250gm	₹41049	2022-05-26	Buy

Product number	Packaging	Price	Buy
N3510	50G	₹11961.63	Buy
N3510	250G	₹30851.25	Buy
481909	1G	₹4630.01	Buy
N 0636	50gm	₹10809	Buy
N 0636	250gm	₹41049	Buy

Niclosamide Chemical Properties,Uses,Production

Chemical Properties

Yellowish-white or yellowish, fine crystals.Yellow-white crystalline powder, odorless, tasteless. Melting point 225-230 ℃. Insoluble in water, soluble in hot ethanol, chloroform, cyclohexanone, diethyl ether and sodium hydroxide solution.

Uses

Niclosamide has been used extensively in the treatment of tapeworm infections caused by Taenia saginata, Taenia solium, Diphyllobothrium latum, Fasciolopsis buski, and Hymenolepis nana. It is an effective alternative to praziquantel for treating infections caused by T. saginata (beef tapeworm), T. solium (pork tapeworm), and D. latum (fish tapeworm) and is active against most other tapeworm infections. It is absorbed by intestinal cestodes but not nematodes.A single dose is usually adequate to produce a cure rate of 95%.With H. nana (dwarf tapeworm), a longer treatment course (up to 7 days) is necessary. Niclosamide is administered orally after the patient has fasted overnight and may be followed in 2 hours by purging (magnesium sulfate 15–30 g) to encourage complete expulsion of the cestode, especially T. solium, although this is not always considered necessary. Cure is assessed by follow-up stool examination in 3 to 5 months.With the availability of other agents, niclosamide is no longer widely used.The most widely employed agents are praziquantel and the benzimidazoles.

Antimicrobial activity

Useful activity is restricted to intestinal tapeworms, including Taeniarhynchus saginatus (syn. Taenia saginata), Taenia solium, Diphyllobothrium latum and Hymenolepis nana. It is not effective against larval stages of tapeworms.

General Description

A cell-permeable salicylanilide that, in addition to its well-known antihelmintic efficacy, acts as a mammalian mTORC1, but not mTORC2, signaling inhibitor mechanistically distinct from rapamycin. Likely a direct consequence of autophagy activation, Niclosamide is demonstrated to induce Wnt-independent Frizzled1 and Dishevelled-2 downregulation. Unrelated to its autophagy induction activity, Niclosamide is also shown to inhibit Stat3 signaling (IC₅₀ = 0.25 M in HeLa reporter assays). Efficiently inhibits breast cancer stem-like cells in vitro and in vivo.

Pharmaceutical Applications

A synthetic chlorinated nitrosalicylanilide available for oral administration.

Mechanism of action

For many years, niclosamide (Niclocide) was widely used to treat infestations of cestodes. Niclosamide is a chlorinated salicylamide that inhibits the production of energy derived from anaerobic metabolism. It may also have adenosine triphosphatase (ATPase) stimulating properties. Inhibition of anaerobic incorporation of inorganic phosphate into ATP is detrimental to the parasite. Niclosamide can uncouple oxidative phosphorylation in mammalian mitochondria, but this action requires dosages that are higher than those commonly used in treating worm infections.
The drug affects the scolex and proximal segments of the cestodes, resulting in detachment of the scolex from the intestinal wall and eventual evacuation of the cestodes from the intestine by the normal peristaltic action of the host's bowel. Because niclosamide is not absorbed from the intestinal tract, high concentrations can be achieved in the intestinal lumen.The drug is not ovicidal.

Pharmacokinetics

Conflicting data exist relative to the level of absorption of niclosamide from the gut. The metabolized drug is passed in the feces and urine, staining them yellow.

Clinical Use

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamideor 2,5 -dichloro-4 -nitrosalicylanilide (Cestocide, Mansonil,Yomesan) occurs as a yellowish white, water-insolublepowder. It is a potent taeniacide that causes rapid disintegrationof worm segments and the scolex. Penetration of thedrug into various cestodes appears to be facilitated by thedigestive juices of the host, in that very little of the drug isabsorbed by the worms in vitro. Niclosamide is well toleratedfollowing oral administration, and little or no systemicabsorption of it occurs. A saline purge 1 to 2 hours after ingestion of the taeniacide is recommended to remove thedamaged scolex and worm segments. This procedure ismandatory in the treatment of pork tapeworm infestation toprevent possible cysticercosis resulting from release of liveova from worm segments damaged by the drug.

Side effects

No serious side effects are associated with niclosamide use, although some patients report abdominal discomfort and loose stools.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl and NOx.

Niclosamide Preparation Products And Raw materials

Raw materials

Phosphorus oxychloride 2-Chloro-4-nitroaniline 5-Chloro-2-hydroxybenzoic acid Phosphorus trichloride

Preparation Products

Niclosamide Suppliers

Global( 464)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Siflon Drugs	+917780793600	Hyderabad, India	12	58	Inquiry
Sri Yadadri Lifesciences Pvt Ltd	+91-8466997432 +91-8466997432	Hyderabad, India	1	58	Inquiry
Adani Wilmar Limited	+91-7383819375 +91-9099656790	Gujarat, India	34	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
D H O Organics	+91-9821028610 +91-8879777537	Maharashtra, India	12	58	Inquiry
Manasvi Life Sciences	+91-9391326151 +91-9490072008	Hyderabad, India	39	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Adani Pharmachem Pvt Ltd	+91-7573044087 +91-9974652373	Gujarat, India	27	58	Inquiry
Elppe Chemicals Private Limited	+91-2240109150 +91-2240159160	Maharashtra, India	34	58	Inquiry
Nulli Secondus Impex Pvt Ltd	+91-9440404566 +91-9440404566	Telangana, India	15	58	Inquiry

Supplier	Advantage
Siflon Drugs	58
Sri Yadadri Lifesciences Pvt Ltd	58
Adani Wilmar Limited	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
D H O Organics	58
Manasvi Life Sciences	58
Ralington Pharma	58
Adani Pharmachem Pvt Ltd	58
Elppe Chemicals Private Limited	58
Nulli Secondus Impex Pvt Ltd	58

Niclosamide Spectrum

Niclosamide(50-65-7)¹HNMR

50-65-7(Niclosamide)Related Search:

N-Methyl-4-nitroaniline 4'-Nitroacetanilide Sodium salicylate CHLOROPHOSPHONAZO III Salicylanilide

Niclosamide ethanolamine salt N-{2-chloro-4-nitrophenyl}-2-hydroxybenzamide 3,5-dichloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide Benzamide, 3-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy- Niclosamide-13C6

NIACINAMIDE ASCORBATE N-(4-Nitrophenyl)-5-chlorosalicylamide Niclosamide-d6 β-D-Glucopyranosiduronic acid, 4-chloro-2-[[(2-chloro-4-nitrophenyl)amino]carbonyl]phenyl 4-Nitroaniline

Difluorochloromethane 2-Nitroaniline 2-Chloro-1,4-benzenediamine hydrochloride

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Nc osamide NICLOSAMID PESTANAL 250 MG NICLOSAMID PESTANAL 2-CHLORO-4-NITROHENYLAMIDE-6-CHLOROSALICYLIC ACID Niclosamide 1420-04-8, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza Niclosamide (base and/or unspecified salts) 5-CHLORO-N-(2-CHLORO-5-NITROPHENYL)-2-HYDROXYBENZAMIDE 2-hydroxy-5-chlorobenzanone acid 4-nitro-2-chloranylnide Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy- Bayluscid W.P. Bayluscid E.C. Niclosamide,2′,5-Dichloro-4′-nitrosalicylanilide Niclosamide 250mg [50-65-7] NiclosaMide, Anhydrous, BP Chloro nitrohenylamide chlorosalicylic acid NiclosaMide USP 2’,5-dichlor-4’-nitro-salizylsaeureanilid 2’,5-dichlor-4’-nitro-salizylsaeureanilid[german] 2’,5-dichloro-4’-nitro-salicylanilid 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamid 5-chlorosalicyloyl-(o-chloro-p-nitranilide) b2353 bay2353 bayer2353 cestocid chemagro2353 devermin devermine dichlosale ent25823 fedal-telmin fenasal helmiantin hl2447 iomesan iomezan lintex mansonil mato n-(2’-chlor-4’-nitrophenyl)-5-chlorsalicylamid n-(2-chloro-4-nitrophenyl)-5-chlorosalicylamide nasemo nitrophenylchlorsalicylamide phenasal radeverm sagimid sulqui vermitid wr46234 NiclosaMide 0 MANSONIL(R) BAYLUSCIDE BAYLUSCIDE(R) NICLOSAMIDE YOMESAN(R) 2',5-DICHLORO-4'-NITROSALICYLANILIDE 2',5-DICHLORO-4-NITROSALICYLANILIDE