Sodium salicylate
- CAS No.
- 54-21-7
- Chemical Name:
- Sodium salicylate
- Synonyms
- SALICYLATE;NASAL;alysine;2-Hydroxybenzoate;clin;ardall;aroall;kerosal;nadisal;salisod
- CBNumber:
- CB1255762
- Molecular Formula:
- C7H5NaO3
- Molecular Weight:
- 160.1
- MOL File:
- 54-21-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | >300 °C (lit.) |
|---|---|
| Density | 0.32 g/cm3 (20℃) |
| storage temp. | Store at +15°C to +25°C. |
| solubility | 1000g/l |
| form | Crystals or Crystalline Powder |
| color | White |
| Odor | wh. lustrous cryst. scales or amorphous powd., odorless or faint odor, saline taste |
| PH | 6.5 (100g/l, H2O, 20℃) |
| Water Solubility | 1000 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,8332 |
| BRN | 3732792 |
| Stability | Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive. |
| InChIKey | ABBQHOQBGMUPJH-UHFFFAOYSA-M |
| LogP | 2.061 (est) |
| CAS DataBase Reference | 54-21-7(CAS DataBase Reference) |
| EPA Substance Registry System | Sodium salicylate (54-21-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H361d | |||||||||
| Precautionary statements | P201-P202-P264-P301+P312-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41-36/37/38-36 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | VO5075000 | |||||||||
| F | 8 | |||||||||
| Autoignition Temperature | >250 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29182100 | |||||||||
| Toxicity | LD50 i.p. in rats: 780 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Sodium salicylate price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S3007 | Sodium salicylate ReagentPlus?, ≥99.5% | 54-21-7 | 500G | ₹11626.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S3007 | Sodium salicylate ReagentPlus?, ≥99.5% | 54-21-7 | 1KG | ₹13076.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S3007 | Sodium salicylate ReagentPlus?, ≥99.5% | 54-21-7 | 5KG | ₹31457.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S2679 | Sodium salicylate meets USP testing specifications | 54-21-7 | 100G | ₹5180 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S2679 | Sodium salicylate meets USP testing specifications | 54-21-7 | 500G | ₹19660 | 2022-06-14 | Buy |
Sodium salicylate Chemical Properties,Uses,Production
Description
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.
Chemical Properties
Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative.
Uses
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons.
Definition
A salt or ester of salicylic acid.
General Description
Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.
Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin.
Safety Profile
Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O.
Sodium salicylate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Murli Krishna Exports Pvt Ltd | +91-2225631595 +91-2225631594 | New Delhi, India | 185 | 58 | Inquiry |
| Covalent Incorporation | +91-9033666099 +91-9033666099 | Gujarat, India | 50 | 58 | Inquiry |
| Salicylates and Chemicals Pvt. Ltd. | +91-8879630551 +91-8898005838 | Maharashtra, India | 61 | 58 | Inquiry |
| Merck Ltd | +91-2262109800 +91-2262109000 | Maharashtra, India | 272 | 58 | Inquiry |
| Siddharth Carbochem Products Ltd. (SCPL) | +91-2262454545 +91-2262454545 | Maharashtra, India | 6 | 58 | Inquiry |
| The Andhra Sugars Limited | +91-9346009958 +91-8819221423 | AndhraPradesh, India | 11 | 58 | Inquiry |
| Alta Laboratories Ltd | +91-8828332244 +91-8828332244 | Maharashtra, India | 10 | 58 | Inquiry |
| RYZE CHEMIE | +91-9702966440 +91-9702966440 | Maharashtra, India | 335 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Related articles
- Anti-inflammatory Properties of Sodium Salicylate: Effects on Intracellular Signaling Pathways and Other Non-Cyclooxygenase Effects
- Sodium salicylate inhibits kinases and transcription factors, including NF-nB, while stimulating adenosine release, contributi....
- Jan 11，2024
- Sodium salicylate:Activity, Application and Chemical Studies
- Sodium Salicylate Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in ag....
- Feb 15，2023
- Sodium Salicylate vs Aspirin
- Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF κ B and reduces oxidativ....
- Jan 20，2022