Ceftobiprole

CAS No.: 209467-52-7

Chemical Name:: Ceftobiprole

Synonyms: CS-734;BAL 9141;Ceftobiprole;Abscisic Acid Impurity 4;cephalosporin,Ceftobiprole,inhibit,vancomycin,penicillin,staphylococci,Bacterial,pyrrolidinone,pathogens,gram-positive,BAL-9141,VRSA,gram-negative,Inhibitor,MRSA,BAL9141,methicillin;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-

CBNumber:: CB61509106

Molecular Formula:: C20H22N8O6S2

Molecular Weight:: 534.57

MOL File:: 209467-52-7.mol

MSDS File:: SDS

Modify Date:: 2025/4/27 15:04:49

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Ceftobiprole Properties

Density	2.00±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO : 5 mg/mL (9.35 mM)
form	Solid
pka	2.46±0.50(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Signal word	Danger
Hazard statements	H334-H317-H302
Precautionary statements	P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501

Ceftobiprole Chemical Properties,Uses,Production

Uses

Broad spectrum antibiotic.

Antimicrobial activity

The most important property distinguishing it from older cephalosporins is activity against methicillin-resistant staphylococci, a property conferred by a high affinity for penicillinbinding protein 2′ (2a). MICs for methicillin-resistant strains are nevertheless somewhat higher than those seen with fully susceptible strains. A similar situation exists with coagulasenegative staphylococci and with Str. pneumoniae, for which strains with reduced susceptibility to penicillin are less susceptible than fully resistant strains, while remaining within therapeutically achievable levels.
Otherwise activity approximates to that of cephalosporins of group 4 . Activity against Ps. aeruginosa is modest and much reduced against ceftazidime-resistant strains.

Acquired resistance

It is hydrolyzed by extended spectrum β-lactamases of enterobacteria , which are therefore resistant. The prospects for the emergence of resistance during extensive clinical use are presently unclear, though increased resistance in Staph. aureus appears to be difficult to induce under laboratory conditions.

Pharmacokinetics

C_{max 500 mg (667 mg prodrug): c. 35 mg/L end infusion

intravenous (30-min infusion)

Plasma half-life: c. 3 h

Volume of distribution: 18.4 L

Plasma protein binding: 16%

The prodrug is rapidly hydrolyzed in plasma to release the
active form together with diacetyl (2,3-butanediol) and CO2.
Distribution approximates to the extracellular fluid volume in
adults. There is no accumulation on repeat dosing in subjects
with normal renal function.

It is chiefly excreted in urine by glomerular filtration. A urinary
concentration exceeding 1 g/L is achieved within the first
2 h of a 500 mg (active drug equivalent) dose and 80–90% of
active drug can be recovered within 24 h.}

Clinical Use

Ceftobiprole can be used as Broad spectrum antibiotic and in complicated infections of skin and skin structures.

Side effects

Limited studies have so far revealed no unexpected side effects. Nausea, vomiting and altered taste sensation appear to be the most common.

Ceftobiprole Preparation Products And Raw materials

Raw materials

Preparation Products

Ceftobiprole Suppliers

Global( 70)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6514	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	China	5868	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29857	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19552	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
Alfa Chemistry		United States	24072	58	Inquiry
TargetMol Chemicals Inc.		United States	38652	58	Inquiry

Supplier	Advantage
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
career henan chemical co	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58

Ceftobiprole: Antimicrobial Activity, Susceptibility, Administration and Dosage, Clinical Uses etc.
Ceftobiprole, formerly BAL9141 or Ro 63-9141, is a novel pyrrolidinone-3-ylidene-methyl cephalosporin with clinically demonst....
Mar 25，2022

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Ceftobiprole 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)- CS-734 BAL 9141 cephalosporin,Ceftobiprole,inhibit,vancomycin,penicillin,staphylococci,Bacterial,pyrrolidinone,pathogens,gram-positive,BAL-9141,VRSA,gram-negative,Inhibitor,MRSA,BAL9141,methicillin Abscisic Acid Impurity 4 209467-52-7