5-Bromo-2-chloropyridine

- CAS No.
- 53939-30-3
- Chemical Name:
- 5-Bromo-2-chloropyridine
- Synonyms
- N-methyl-1-(pyridin-3-yl)methanamine;CL025;2-cholro-5-broMopyridine;2-CHLORO-5-BROMOPYRIDINE;5-BROMO-2-CHLOROPYRIDINE;3-Bromo-6-chloropyridine;5-Bromo-2-chloro pyridne;5-bromo-2-chlorolpyridine;PYRIDINE, 5-BROMO-2-CHLORO-;2-chloro -5-pyridyl broMide
- CBNumber:
- CB6177511
- Molecular Formula:
- C5H3BrClN
- Molecular Weight:
- 192.44
- MOL File:
- 53939-30-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
Melting point | 65-69 °C (lit.) |
---|---|
Boiling point | 208.1±20.0 °C(Predicted) |
Density | 1.7783 (rough estimate) |
refractive index | 1.5400 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
pka | -2.25±0.10(Predicted) |
form | Crystalline Powder or Crystals |
color | Off-white |
BRN | 108887 |
InChI | InChI=1S/C5H3BrClN/c6-4-1-2-5(7)8-3-4/h1-3H |
InChIKey | PEAOEIWYQVXZMB-UHFFFAOYSA-N |
SMILES | C1(Cl)=NC=C(Br)C=C1 |
CAS DataBase Reference | 53939-30-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | T | |||||||||
HazardClass | IRRITANT, IRRITANT-HARMFUL | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
|
5-Bromo-2-chloropyridine price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 551902 | 5-Bromo-2-chloropyridine 95% | 53939-30-3 | 5G | ₹1569.63 | 2022-06-14 | Buy |
Sigma-Aldrich | 551902 | 5-Bromo-2-chloropyridine 95% | 53939-30-3 | 25G | ₹6191.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 551902 | 5-Bromo-2-chloropyridine 95% | 53939-30-3 | 25G | ₹6191.9 | 2022-06-14 | Buy |
TCI Chemicals (India) | B2329 | 5-Bromo-2-chloropyridine min. 98.0 % | 53939-30-3 | 5G | ₹2100 | 2022-05-26 | Buy |
ALFA India | ALF-B24862-14 | 5-Bromo-2-chloropyridine, 98% | 53939-30-3 | 25g | ₹2702 | 2022-05-26 | Buy |
5-Bromo-2-chloropyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromo-2-chloropyridine may be used in the preparation of following compounds:
- Amino-2-chloropyridine via palladium-catalyzed amination.
- 5-Bromo-2-fluoropyridine via halogen-exchange reaction using anhydrous potassium fluoride.
- 2-Chloro-5-(2,5-dimethoxyphenyl)pyridine via Suzuki coupling with 2,5-dimethoxyphenylboronic acid.
Synthesis
6-Chloro-pyridin-3-ylamine was dissolved slowly with constant stirring in 48% HBr solution (50 mL) at r.t. and then the solution was cooled to -10 °C. A solution of sodium nitrite in cold water was added dropwise at -10 °C with constant stirring over 2 h, followed by a solution of copper (I) bromide in 48% HBr dropwise. The mixture was then stirred at r.t. until complete. The mixture was neutralized with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1% ethyl acetate/petroleum ether to afford 5- bromo-2-chloropyridine.
5-Bromo-2-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
chevron_rightSupplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
GLR Innovations | +91 9891111994 | New Delhi, India | 4535 | 58 | Inquiry |
Terma Medicare India Pvt.,Ltd | +86-53530655; +8613916485955 | Shanghai, India | 184 | 58 | Inquiry |
JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
GK Chemicals | +91-7207279444 +91-7207279444 | Hyderabad, India | 340 | 58 | Inquiry |
Gravitas Pharma Pvt Ltd | +91-9177758787 +91-9177758787 | Hyderabad, India | 103 | 58 | Inquiry |
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED | +919966658228 | Hyderabad, India | 486 | 58 | Inquiry |
Varna Chems | +91-9030000693 +91-9030000693 | Hyderabad, India | 483 | 58 | Inquiry |
SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
JUVENUS DRUGS | +91-9655606404 +91-9655606404 | Tamil Nadu, India | 94 | 58 | Inquiry |
CHATURYA BIOTECH | +91-7702707258 +91-7702707258 | Telangana, India | 479 | 58 | Inquiry |
Supplier | Advantage |
---|---|
GLR Innovations | 58 |
Terma Medicare India Pvt.,Ltd | 58 |
JSK Chemicals | 58 |
GK Chemicals | 58 |
Gravitas Pharma Pvt Ltd | 58 |
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED | 58 |
Varna Chems | 58 |
SVH BIOSCIENCES | 58 |
JUVENUS DRUGS | 58 |
CHATURYA BIOTECH | 58 |
53939-30-3(5-Bromo-2-chloropyridine)Related Search:
1of4
chevron_right