ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Nitropyridine >2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine

CAS No.: 4548-45-2

Chemical Name:: 2-Chloro-5-nitropyridine

Synonyms: Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine;6-Chloro-3-nitropyridine

CBNumber:: CB8853635

Molecular Formula:: C5H3ClN2O2

Molecular Weight:: 158.54

MOL File:: 4548-45-2.mol

MSDS File:: SDS

Modify Date:: 2024/5/14 16:41:43

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2-Chloro-5-nitropyridine Properties

Melting point	105-108 °C (lit.)
Boiling point	256.6±20.0 °C(Predicted)
Density	1.6616 (rough estimate)
refractive index	1.5500 (estimate)
Flash point	158°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-4.22±0.10(Predicted)
form	Crystalline Powder
color	Light yellow to beige
Water Solubility	Solubility in hot methanol. Insoluble in water.
BRN	120453
InChI	InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey	BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference	4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference	2-Chloro-5-nitropyridine(4548-45-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

RTECS

US7175000

HazardClass

IRRITANT

HS Code

29333990

NFPA 704

	1
2		0

2-Chloro-5-nitropyridine price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C61801	2-Chloro-5-nitropyridine 99%	4548-45-2	5G	₹3139.25	2022-06-14	Buy
Sigma-Aldrich(India)	C61801	2-Chloro-5-nitropyridine 99%	4548-45-2	25G	₹7685.75	2022-06-14	Buy
TCI Chemicals (India)	C0025	2-Chloro-5-nitropyridine min. 99.0 %	4548-45-2	5G	₹2000	2022-05-26	Buy
ALFA India	ALF-A10709-22	2-Chloro-5-nitropyridine, 99%	4548-45-2	100g	₹25146	2022-05-26	Buy
TCI Chemicals (India)	C0025	2-Chloro-5-nitropyridine min. 99.0 %	4548-45-2	25G	₹7100	2022-05-26	Buy

Product number	Packaging	Price	Buy
C61801	5G	₹3139.25	Buy
C61801	25G	₹7685.75	Buy
C0025	5G	₹2000	Buy
ALF-A10709-22	100g	₹25146	Buy
C0025	25G	₹7100	Buy

2-Chloro-5-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxychloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine

2-Amino-6-chloro-3-nitropyridine 2-Chloro-5-nitropyridin-4-amine

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Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL 5-AMINO-2-METHOXY-ISONICOTINIC ACID 6-(1-PYRROLIDINYL)-3-PYRIDINAMINE

1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE 5-Amino-2-chloropyridine

5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 3-Aminopyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine

2-Chloro-5-nitropyridin-4-amine NVP-LDE225 2-Methyl-5-nitropyridine

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2-Chloro-5-nitropyridine Suppliers

Global( 659)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Terma Medicare India Pvt.,Ltd	+8613916485955	Rajasthan, India	145	58	Inquiry
BTC pharm India	+918790379245	AndhraPradesh, India	1269	58	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4542	58	Inquiry
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED	+919966658228	Hyderabad, India	486	58	Inquiry
ALS INDIA LIFE SCIENCES	+91-8977036379 +91-8977036379	Hyderabad, India	1879	58	Inquiry
Jubilant Ingrevia	+91-1204361000 +91-1204361000	Uttar Pradesh, India	142	58	Inquiry
Madin Life Sciences Pvt Ltd	+91-9014759900 +91-9014759900	Telangana, India	230	58	Inquiry
Vital synthetics	+917799889789	Telangana, India	98	58	Inquiry
RPN ORGANICS PVT LTD	+919010289956	Telangana, India	166	58	Inquiry
Hyderabad	+91-9676447615 +91-9676447615	Telangana, India	192	58	Inquiry

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
BTC pharm India	58
GLR Innovations	58
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED	58
ALS INDIA LIFE SCIENCES	58
Jubilant Ingrevia	58
Madin Life Sciences Pvt Ltd	58
Vital synthetics	58
RPN ORGANICS PVT LTD	58
Hyderabad	58

2-Chloro-5-nitropyridine Spectrum

2-Chloro-5-nitropyridine(4548-45-2)MS 2-Chloro-5-nitropyridine(4548-45-2)¹HNMR 2-Chloro-5-nitropyridine(4548-45-2)IR1 2-Chloro-5-nitropyridine(4548-45-2)IR2

4548-45-2(2-Chloro-5-nitropyridine)Related Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol

1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine

3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE 2-Chloro-5-iodopyridine

5-Bromo-2-chlorobenzoic acid 2,4-DICHLORO-5-NITROPYRIDINE Difluorochloromethane

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2-Chloro-5-nitropyridine 3-Nitro-6-chloropyridine 2-Chloro-5-nitropyridine, 99% 25GR 5-Nitro-2-chloropyridine 6-Chloro-3-nitropyridine 2-Chloro-5-nitropyridine, 97+% Chloro-5-nitropyrid 2-chloro-5-nitro-pyridin Chloronitropyridine,99% 3-PYRIDINOL, 6-CHLORO- 2-choro-5-nitropyridine 2-CHLORO-5-NITROPYRIDINE (NON-REGULATED) 2-CHLORO-5-NITROPYRIDINE (REGULATED) 2-CHLORO-5-NITROPYRIDINE 99+% Chloronitropyridine 2-Chloro-5-nitropyridine > 5-Bromo-4-methyl-2(2H)-pyridinone 4548-45-2 ISO 9001：2015 REACH 2-Chloro-5-nitropyridine ISO 9001：2015 REACH 2-Chloro--nitropyridine 2-chloro-5-nitripyridine Piroctone Impurity 3 4548-45-2 4548-48-2 C5H3CIN2O2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles alkyl chloride |nitro-compound Chlorinated heterocyclic series Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridine series Halides Pyridines derivates Pyridines, Pyrimidines, Purines and Pteredines Heterocycles blocks Pyridines Pyridine compounds of pyridine 1 bc0001