FR 122047 HYDROCHLORIDE

CAS No.: 130717-51-0

Chemical Name:: FR 122047 HYDROCHLORIDE

Synonyms: FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE

CBNumber:: CB6178619

Molecular Formula:: C23H26ClN3O3S

Molecular Weight:: 459.99

MOL File:: 130717-51-0.mol

MSDS File:: SDS

Modify Date:: 2023/9/20 16:43:00

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FR 122047 HYDROCHLORIDE Properties

storage temp.	2-8°C
solubility	methylene chloride: 50 mg/mL, slightly hazy, yellow
form	powder
color	faint yellow
Water Solubility	Soluble to 10 mM in water

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

FR 122047 HYDROCHLORIDE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	F7553	FR 122047 hydrochloride ≥98% (HPLC), powder	130717-51-0	25MG	₹54742.03	2022-06-14	Buy
Sigma-Aldrich(India)	236005	COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is prim	130717-51-0	5MG	₹20250	2022-06-14	Buy

Product number	Packaging	Price	Buy
F7553	25MG	₹54742.03	Buy
236005	5MG	₹20250	Buy

FR 122047 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

Uses

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

FR 122047 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

FR 122047 HYDROCHLORIDE Suppliers

Global( 35)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Suzhou Chenrui Biotechnology Co. LTD	17625585511	China	530	58	Inquiry
Hangzhou FuRun Pharmaceutical Technology Co., Ltd	15658004993	China	960	58	Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	China	11289	58	Inquiry
United States Biological	800.520.3011 or 781.639.5092	United States	6256	80	Inquiry
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	China	8141	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Suzhou Chenrui Biotechnology Co. LTD	58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
United States Biological	80
MedBioPharmaceutical Technology Inc	58

FR 122047 HYDROCHLORIDE Spectrum

FR 122047 HYDROCHLORIDE(130717-51-0)¹HNMR

130717-51-0(FR 122047 HYDROCHLORIDE)Related Search:

4,5-DIPHENYL-2-METHYLTHIAZOLE 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE 4-PHENYL-THIAZOLE-2-CARBALDEHYDE (4-METHYL-1,3-THIAZOL-2-YL)METHYLAMINE FR 122047 HYDROCHLORIDE

N-Methylthiazole-2-methanamine C-(4-PHENYL-THIAZOL-2-YL)-METHYLAMINE 5-Methyl-1,3-thiazole-2-carboxaldehyde 1,3-Thiazole-2-carbaldehyde 1-THIAZOL-2-YLMETHYL-PIPERAZINE

4-METHYL-2-THIAZOLECARBOXALDEHYDE 97 1,3-Thiazole-2-carboxamide 2-AMINOMETHYLTHIAZOLE HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYL-PIPERAZINE, MONOHYDROCHLORIDE HYDRATE

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4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE 4,5-BIS(4-METHOXYPHENYL)-2-[(1-METHYLPIPERAZINE-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE 1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE FR 122047 FR 122047 HYDROCHLORIDE FR122047HCl (4,5-Bis(4-Methoxyphenyl)thiazol-2-yl)(4-Methylpiperazin-1-yl)Methanone hydrochloride (4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl Methanone, [4,5-bis(4-methoxyphenyl)-2-thiazolyl](4-methyl-1-piperazinyl)-, hydrochloride (1:1) 5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole 5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine [4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem FR 122047 hydrochloride,Cyclooxygenase,FR 122047,FR122047,inhibit,Inhibitor,COX,FR-122047 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride|||1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride 130717-51-0 C23H25N3O3SHCl A to C Biochemicals and Reagents BioChemical Cyclooxygenase Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Enzyme Prostanoid receptor and related