ANSAMITOCIN P-3
- CAS No.
- 66547-09-9
- Chemical Name:
- ANSAMITOCIN P-3
- Synonyms
- ASMP-3;CS-1373;c15003p-3’;Aansamitocin P3;ANSAMITOCIN P-N;Maytansinoid AP-3;antibioticc15003p3’;maytansinolbutyrate;Ansamitocin P-3, >=70%;Ansamitocin P-3 (≥90%)
- CBNumber:
- CB6205964
- Molecular Formula:
- C32H43ClN2O9
- Molecular Weight:
- 635.14
- MOL File:
- 66547-09-9.mol
- Modify Date:
- 2023/6/8 9:02:48
| Melting point | 182-185℃ |
|---|---|
| Boiling point | 837.6±65.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming). |
| pka | 9.83±0.70(Predicted) |
| form | White to off-white crystalline solid. |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OQ2293000 | |||||||||
| NFPA 704 |
|
ANSAMITOCIN P-3 Chemical Properties,Uses,Production
Description
Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.
ANSAMITOCIN P-3 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 177)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10260 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
66547-09-9(ANSAMITOCIN P-3)Related Search:
3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-maytansinbutyrate(ester
Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
Maytansine, o(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup 3)-(1-oxobutyl)- (9ci)
Ansamitocin P-3, >=70%
Maytansinoid AP-3
ANSAMITOCIN P-N
Aansamitocin P3
3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansinebutyrate(ester)
antibioticc15003p3’
c15003p-3’
maytansine,o(sup3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup3)-(1-oxobut
maytansinolbutyrate
ASMP-3
ANSAMITOCIN P-3, ACTINOSYNNEMA PRETIOSUM
ANSAMITOCIN P-3 FROM ACTINOSYNNEMAPRETIO SUM
Maytansine, 2-de(acetylmethylamino)-2-methyl-
Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-O3-(1-oxobutyl)-
3-O-De[2-[acetyl(methyl)amino]-1-oxopropyl]-3-O-(1-oxobutyl)maytansine
ANTIBIOTIC C 15003P3; MAYTANSINOL BUTYRATE; C15003P3
CS-1373
ANTIBIOTIC C 15003P3';MAYTANSINOL BUTYRATE
Ansamitocin P-3 (≥90%)
Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-
Maytansinol Impurity 1 (Maytansinol Butyrate)(Ansamitocin P-3)
TIANFUCHEM--66547-09-9---ANSAMITOCIN P-3
66547-09-9
65547-09-9
C32H43ClN2O9
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Microtobule Inhibitors
Cytoskeleton and Extracellular Matrix
Inhibitors
Cell Signaling and Neuroscience
Cytoskeleton and Extracellular Matrix
Microtobule Inhibitors
Microtobule Inhibitors
Cell Signaling and Neuroscience
Cytoskeleton and Extracellular Matrix