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NODULARIN

CAS No.: 118399-22-7

Chemical Name:: NODULARIN

Synonyms: NODULARIN;Nodularin-R solution;Nodularin solution ;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE;tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth

CBNumber:: CB6225379

Molecular Formula:: C41H60N8O10

Molecular Weight:: 824.96

MOL File:: 118399-22-7.mol

Modify Date:: 2023/6/8 9:01:56

Request For Quotation

NODULARIN Properties

Density	1.29±0.1 g/cm3(Predicted)
Flash point	11℃
storage temp.	−20°C
solubility	methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form	Dry residue containing traces of monobasic potassium phosphate.
pka	3.39±0.70(Predicted)
IARC	3 (Vol. 94) 2010
EPA Substance Registry System	Nodularin (118399-22-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300+H310+H330-H315-H317-H319-H335

Precautionary statements

P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338

Hazard Codes

T,F,T+

Risk Statements

23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28

Safety Statements

36/37-45-16-7-36/37/39-26

RIDADR

UN 2811 6.1/PG 2

WGK Germany

RTECS

GU2294250

Toxicity

mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.

NFPA 704

	0
4		0

NODULARIN price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N5148	Nodularin cyanotoxin	118399-22-7	250μG	₹56203.4	2022-06-14	Buy
Sigma-Aldrich(India)	32539	Nodularin solution 10?μg/mL in methanol, analytical standard	118399-22-7	1ML	₹43331.4	2022-06-14	Buy

Product number	Packaging	Price	Buy
N5148	250μG	₹56203.4	Buy
32539	1ML	₹43331.4	Buy

NODULARIN Chemical Properties,Uses,Production

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC₅₀ values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC₅₀ of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Uses

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

NODULARIN Preparation Products And Raw materials

Raw materials

Preparation Products

NODULARIN Suppliers

Global( 45)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
BIOMOL INTERNATIONAL, LP	(800) 942-0430	United States	1503	77	Inquiry
Alexis Corporation	+41 61 926 8989	Switzerland	3599	74	Inquiry
MP Biomedicals, Inc.	949 833 2500	United States	6566	81	Inquiry
AXXORA, LLC	+41 (0) 61 926 8989	Switzerland	1104	80	Inquiry
Service Chemical Inc.	888-895-6920	Germany	6373	71	Inquiry
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd	(852)2541 2772	China	6214	58	Inquiry
SIGMA-RBI	800 736 3690 (Orders)	Switzerland	6913	91	Inquiry
Express Technology Co., Ltd.	010-60206266	China	115	30	Inquiry
Riedel-de Haen AG	800 558-9160	United States	6825	87	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry

Supplier	Advantage
BIOMOL INTERNATIONAL, LP	77
Alexis Corporation	74
MP Biomedicals, Inc.	81
AXXORA, LLC	80
Service Chemical Inc.	71
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd	58
SIGMA-RBI	91
Express Technology Co., Ltd.	30
Riedel-de Haen AG	87
Shanghai Hao Zhun Biological Technology Co., Ltd.	58

118399-22-7(NODULARIN)Related Search:

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SALCOMINE N-BUTYLISOCYANIDE Cupric acetylacetonate Benzyl isocyanide Aluminum acetylacetonate

2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TERT-BUTYL ISOCYANIDE

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tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl) NODULARIN 1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE Nodularin, Nodularia spumigena 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl) Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl) Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide Nodularin-R solution Nodularin solution cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar IXBQSRWSVIBXNC-HSKGSTCASA-N Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl] 118399-22-7 C41H60N8O10 Application Index Biochemicals and Reagents BioChemical Cell Signaling Enzymes Cyanobacterial Toxins Enzymes, Inhibitors, and Substrates Natural Products