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NODULARIN
- CAS No.
- 118399-22-7
- Chemical Name:
- NODULARIN
- Synonyms
- NODULARIN;Nodularin-R solution;Nodularin in methanol;Nodularin solution ;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
- CBNumber:
- CB6225379
- Molecular Formula:
- C41H60N8O10
- Molecular Weight:
- 824.96
- MOL File:
- 118399-22-7.mol
- Modify Date:
- 2025/1/27 9:38:02
| Density | 1.29±0.1 g/cm3(Predicted) |
|---|---|
| Flash point | 11℃ |
| storage temp. | −20°C |
| solubility | methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months. |
| form | Dry residue containing traces of monobasic potassium phosphate. |
| pka | 3.39±0.70(Predicted) |
| IARC | 3 (Vol. 94) 2010 |
| EPA Substance Registry System | Nodularin (118399-22-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,F,T+ | |||||||||
| Risk Statements | 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28 | |||||||||
| Safety Statements | 36/37-45-16-7-36/37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU2294250 | |||||||||
| Hazardous Substances Data | 118399-22-7(Hazardous Substances Data) | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993. | |||||||||
| NFPA 704 |
|
NODULARIN price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N5148 | Nodularin cyanotoxin | 118399-22-7 | 250μG | ₹56203.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 32539 | Nodularin solution 10?μg/mL in methanol, analytical standard | 118399-22-7 | 1ML | ₹43331.4 | 2022-06-14 | Buy |
NODULARIN Chemical Properties,Uses,Production
Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Uses
Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
NODULARIN Preparation Products And Raw materials
Raw materials
Preparation Products
NODULARIN Suppliers
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32239 | 58 | Inquiry |
| 4008-099-669 | CHINA | 73043 | 58 | Inquiry | |
| TargetMol Chemicals Inc. | 4008200310 | China | 24739 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
| Neobioscience Co., Ltd. | 4006-800-892 | CHINA | 6207 | 58 | Inquiry |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | China | 177174 | 58 | Inquiry |
| Merck KGaA | 21-20338288 | China | 292394 | 58 | Inquiry |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | China | 233051 | 58 | Inquiry |
| Cayman Chemical Company | 800-364-9897 | China | 27736 | 58 | Inquiry |
| BIOMOL INTERNATIONAL, LP | (800) 942-0430 | United States | 1499 | 77 | Inquiry |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| 58 | |
| TargetMol Chemicals Inc. | 58 |
| Absin Bioscience Inc. | 58 |
| Neobioscience Co., Ltd. | 58 |
| Enzo Biochem Inc | 58 |
| Merck KGaA | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 58 |
| Cayman Chemical Company | 58 |
| BIOMOL INTERNATIONAL, LP | 77 |
118399-22-7(NODULARIN)Related Search:
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tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
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NODULARIN
1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
Nodularin, Nodularia spumigena
1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Nodularin-R solution
Nodularin solution
cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar
IXBQSRWSVIBXNC-HSKGSTCASA-N
Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]
Nodularin in methanol
118399-22-7
C41H60N8O10
Application Index
Biochemicals and Reagents
BioChemical
Cell Signaling Enzymes
Cyanobacterial Toxins
Enzymes, Inhibitors, and Substrates
Natural Products