USNIC ACID
- CAS No.
- 125-46-2
- Chemical Name:
- USNIC ACID
- Synonyms
- usno;Usnic;USNEIN;USNIACIN;UNSICACID;SNIC ACID;USNIC ACID;Usnea acid;usninsaeure;2-USNICACID
- CBNumber:
- CB6237422
- Molecular Formula:
- C18H16O7
- Molecular Weight:
- 344.32
- MOL File:
- 125-46-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:13
| Melting point | 200°C |
|---|---|
| alpha | D16 +509.4° (c = 0.697 in chloroform) |
| Boiling point | 399.43°C (rough estimate) |
| Density | 1.2869 (rough estimate) |
| refractive index | 495 ° (C=0.7, CHCl3) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF:2.5(Max Conc. mg/mL);7.26(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.00±0.40(Predicted) |
| color | White to yellow |
| Merck | 9893 |
| LogP | 2.880 |
| CAS DataBase Reference | 125-46-2(CAS DataBase Reference) |
| EPA Substance Registry System | Usnic acid (125-46-2) |
USNIC ACID Chemical Properties,Uses,Production
Chemical Properties
Crystalline, yellow solid. Insoluble in water; slightly soluble in alcohol and ether.
Uses
Usnic acid is a major metabolite from a number of lichen and fungal species and is perhaps one of the longest known microbial metabolites, first isolated in 1844. Usnic acid exhibits a broad range of biological activity, indeed it is easier to list the bioassays in which it does not exhibit activity. More often than not, potency is low and of limited value. Usnic acid is an important metabolite for dereplication in discovery research programs.
Definition
ChEBI: A member of the class of dibenzofurans that is dibenzo[b,d]furan-1(9bH)-one substituted by acetyl groups at positions 2 and 6, hydroxy groups at positions 3 and 7 and methyl groups at positions 8 and 9b.
Contact allergens
Usnic acid is a component of lichens, also used as a topical antibiotic. Allergic contact dermatitis from lichens occurs mainly occupationally in forestry and horticultural workers, and in lichen pickers.
Purification Methods
This very weak acid is the natural form which is recrystallised from Me2CO, MeOH or *C6H6. At 25o it is soluble in H2O (<0.01%), Me2CO (0.77%), EtOAc (0.88%), MeOCH2CH2OH (0.22%) and furfural (7.32%). [Curd & Robertson J Chem Soc 894 1937, Barton & Brunn J Chem Soc 603 1953, resolution: Dean et al. J Chem Soc 1250 1953, synthesis: Barton et al. J Chem Soc 538 1956, Beilstein 18/5 V 586.]
USNIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Saffron Agro Chem | 09422755645 | Maharashtra, India | 1 | 58 | Inquiry |
| Vikas Enterprises | 09919625252 | Uttar Pradesh, India | 3 | 58 | Inquiry |
| Oxford Pesticides | 09890567748 | Maharashtra, India | 1 | 58 | Inquiry |
| Rallis India Limited | 09845294659 | Karnataka, India | 5 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12459 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | China | 985 | 58 | Inquiry |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | China | 346 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2921 | 58 | Inquiry |
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