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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Structure
CAS No.
3543-73-5
Chemical Name:
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms
ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
CBNumber:
CB62485092
Molecular Formula:
C14H19N3O2
Molecular Weight:
261.32
MOL File:
3543-73-5.mol
Modify Date:
2024/5/21 14:26:51
Request For Quotation

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Properties

Melting point 130-135°C
Boiling point 471.6±25.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 6.73±0.10(Predicted)
color Off-White to Pale Beige
InChI InChI=1S/C14H19N3O2/c1-3-19-14(18)6-4-5-13-16-11-9-10(15)7-8-12(11)17(13)2/h7-9H,3-6,15H2,1-2H3
InChIKey JUMGOLYNZBZPKE-UHFFFAOYSA-N
SMILES C1(CCCC(OCC)=O)N(C)C2=CC=C(N)C=C2N=1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P305+P351+P338
HS Code  2933998090

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production

Chemical Properties

Brown Solid

Uses

1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.

Synthesis

In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Global( 204)Suppliers
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Urantiis Pharmaceuticals Private Limited +918790703567 AndhraPradesh, India 80 58 Inquiry
Rampex Labs Private Limited +91 9168074433 Telangana, India 71 58 Inquiry
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A.R. LIFE SCIENCES PVT. LTD. +91-914040267679 +91-8519993257 Hyderabad, India 100 58 Inquiry
Molkem Chemicals +91-917228022464 +91-7228022464 Ahmedabad, India 138 58 Inquiry
Sris Synthesis Pvt Ltd., +91-9989522441 +91-9989522441 Hyderabad, India 282 58 Inquiry
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KROMOZOME +91-91-9650900955 +91-09650900955 Maharashtra, India 71 58 Inquiry
RANI LIFE SCIENCES PVT LTD +91-8008797507 +91-8008797507 Hyderabad, India 37 58 Inquiry
Lorven therapeutics Pvt Ltd +91-8884110005 +91-8884110005 Hyderabad, India 110 58 Inquiry
Supplier Advantage
Urantiis Pharmaceuticals Private Limited 58
Rampex Labs Private Limited 58
OPULENT PHARMA 58
A.R. LIFE SCIENCES PVT. LTD. 58
Molkem Chemicals 58
Sris Synthesis Pvt Ltd., 58
Credas Labs Pvt Ltd 58
KROMOZOME 58
RANI LIFE SCIENCES PVT LTD 58
Lorven therapeutics Pvt Ltd 58

3543-73-5(1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:

FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate
5-AMINO-1-METHYL-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYL ESTER Ethyl-4-(5-aMino-1-Methy-1H-benzo[d] iMidazol-2-yl)butanoate 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acidethylester 5-amino-1-methyl-2-Benzimidazolebutyric acid ethyl ester 5-AMino-1-Methyl- 4-[5-AMino-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester 1-Methyl-5-aMino-1H-benziMidazole-2-butanoic acid ethyl este BendaMustine hydrochloride interMediate 4-(5-aMino-1-Methyl-1H-benzoiMidazol-2-yl)-butyric acid ethyl esterCAS BendaMustine Dideschloroethyl Ethyl Ester ethyl 4-(5-aMino-1-Methyl-1H-1,3-benzodiazol-2-yl)butanoate ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate Bendamustine Intermediate Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate Bendamustine hydrochloride Intermediates 2 5-(5-amino-1-methyl-2-benzimidazolyl)-1-methoxy-2-pentanone 4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate 1-Methyl-5-amino-1H-benzimidazole-2 endamustine Dideschloroethyl Ethyl Ester 1H-Benzimidazole-2-butanoic acid, 5-amino-1-methyl-, ethyl ester Ethyl4-(5-amino-1-methyl-1Hbenzo[d]imidazole -2-yl)butanoate ETHYL 4-(5-AMINO-1-METHYL-1HBENZIMIDAZOL-2-YL) BUTANOATE ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Hydrochloride Intermediate 3543-73-5 API Manufacturer Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate 3543-73-5 Aromatics Heterocycles Intermediates