1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
![1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Structure](CAS/GIF/3543-73-5.gif)
- CAS No.
- 3543-73-5
- Chemical Name:
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyms
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- CBNumber:
- CB62485092
- Molecular Formula:
- C14H19N3O2
- Molecular Weight:
- 261.32
- MOL File:
- 3543-73-5.mol
- Modify Date:
- 2024/5/21 14:26:51
Melting point | 130-135°C |
---|---|
Boiling point | 471.6±25.0 °C(Predicted) |
Density | 1.21±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
pka | 6.73±0.10(Predicted) |
color | Off-White to Pale Beige |
InChI | InChI=1S/C14H19N3O2/c1-3-19-14(18)6-4-5-13-16-11-9-10(15)7-8-12(11)17(13)2/h7-9H,3-6,15H2,1-2H3 |
InChIKey | JUMGOLYNZBZPKE-UHFFFAOYSA-N |
SMILES | C1(CCCC(OCC)=O)N(C)C2=CC=C(N)C=C2N=1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P305+P351+P338 |
HS Code | 2933998090 |
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.
Synthesis
In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Urantiis Pharmaceuticals Private Limited | +918790703567 | AndhraPradesh, India | 80 | 58 | Inquiry |
Rampex Labs Private Limited | +91 9168074433 | Telangana, India | 71 | 58 | Inquiry |
OPULENT PHARMA | +91-9106692785 +91-9106692785 | Gujarat, India | 479 | 58 | Inquiry |
A.R. LIFE SCIENCES PVT. LTD. | +91-914040267679 +91-8519993257 | Hyderabad, India | 100 | 58 | Inquiry |
Molkem Chemicals | +91-917228022464 +91-7228022464 | Ahmedabad, India | 138 | 58 | Inquiry |
Sris Synthesis Pvt Ltd., | +91-9989522441 +91-9989522441 | Hyderabad, India | 282 | 58 | Inquiry |
Credas Labs Pvt Ltd | +91 9133918031 | Hyderabad, India | 119 | 58 | Inquiry |
KROMOZOME | +91-91-9650900955 +91-09650900955 | Maharashtra, India | 71 | 58 | Inquiry |
RANI LIFE SCIENCES PVT LTD | +91-8008797507 +91-8008797507 | Hyderabad, India | 37 | 58 | Inquiry |
Lorven therapeutics Pvt Ltd | +91-8884110005 +91-8884110005 | Hyderabad, India | 110 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Urantiis Pharmaceuticals Private Limited | 58 |
Rampex Labs Private Limited | 58 |
OPULENT PHARMA | 58 |
A.R. LIFE SCIENCES PVT. LTD. | 58 |
Molkem Chemicals | 58 |
Sris Synthesis Pvt Ltd., | 58 |
Credas Labs Pvt Ltd | 58 |
KROMOZOME | 58 |
RANI LIFE SCIENCES PVT LTD | 58 |
Lorven therapeutics Pvt Ltd | 58 |