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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Structure
CAS No.
3543-74-6
Chemical Name:
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms
Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A
CBNumber:
CB92485093
Molecular Formula:
C18H27N3O4
Molecular Weight:
349.42
MOL File:
3543-74-6.mol
MSDS File:
SDS
Modify Date:
2024/3/28 13:39:29
Request For Quotation

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Properties

Melting point 98-101°C
Boiling point 580.6±50.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.26±0.10(Predicted)
color White to Brown

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H341-H351-H361fd
Precautionary statements  P201-P202-P264-P270-P280-P301+P310
HS Code  2933998350

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production

Chemical Properties

Off-White to Light Tan Solid

Uses

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%. 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

2,2'-[[4-(methylamino)-3-nitrophenyl]imino]bisethanol 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-2,3-dihydro-2-hydroxy-1-methyl- oxirene 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid Pentanoic acid, 5-[(2-fluoro-5-nitrophenyl)amino]-5-oxo-
2-Fluoro-5-nitroaniline 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-nitro-2-benzimidazolebutyric acid 2,2'-[(4-fluoro-3-nitrophenyl)imino]bisethanol 1-Methyl-5-nitro-1H-benzimidazole-2-butanoic Acid Ethyl Ester
ETHYLENE OXIDE 2-Bromoethanol Ethanol
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Preparation Products

Bendamustine hydrochloride

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Global( 183)Suppliers
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CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
Anant Pharmaceuticals Pvt Ltd +91-8550986868 +91-9485998001 Haryana, India 461 58 Inquiry
Urantiis Pharmaceuticals Private Limited +918790703567 AndhraPradesh, India 80 58 Inquiry
Lorven therapeutics Pvt Ltd +91-8884110005 +91-8884110005 Hyderabad, India 110 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
Aavyan Labs +91-9652399498 +91-9652399498 Telangana, India 60 58 Inquiry
Myosynth Laboratories Pvt Ltd +91-8913266227 +91-9885891884 AndhraPradesh, India 49 58 Inquiry
Olympus Chemicals & Fertilizers 08068441058Ext 121 Maharashtra, India 486 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
KKyemistry (India) Pvt. Ltd. +91 (40) 2351-0950 New Delhi, India 197 50 Inquiry
Supplier Advantage
CLEANCHEM LABORATORIES LLP 58
Anant Pharmaceuticals Pvt Ltd 58
Urantiis Pharmaceuticals Private Limited 58
Lorven therapeutics Pvt Ltd 58
GLP Pharma Standards 58
Aavyan Labs 58
Myosynth Laboratories Pvt Ltd 58
Olympus Chemicals & Fertilizers 58
Pharma Affiliates 58
KKyemistry (India) Pvt. Ltd. 50

3543-74-6(5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride
BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid
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Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester 4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate Bendamustine Related Impurity 1 1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester 1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester 5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est Bendamustine hydrochloride Intermediates 1 Bendamustine Dihydroxy Ester [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related ethyl 4-(5-(bis(2-hydroxyethyl)amino) Bendamustine USP RC C Bendamustine USP Related Compound C Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate 5-[Bis(2-hydroxyethyl)amino]-1-meth Bendamustine Impurity 40 Bendamustine Related Compound C Bendamustine USP RC C /Bendamustine Impurity A [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano... 5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel Bendamustin Impurity-A (USP related compound C) Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate 3543-74-6 543-74-6 intermediate Aromatics Intermediates & Fine Chemicals Pharmaceuticals