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BEPOTASTINE BESILATE

BEPOTASTINE BESILATE Structure
CAS No.
190786-44-8
Chemical Name:
BEPOTASTINE BESILATE
Synonyms
BB;Talion;CS-645;CS-487;Bepreve;TAU 284;Talion (TN);Benzestatine;Betastine besylate;Bepotastine Besylate
CBNumber:
CB9810068
Molecular Formula:
C27H31ClN2O6S
Molecular Weight:
547.06
MOL File:
190786-44-8.mol
Modify Date:
2024/10/31 20:01:59
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BEPOTASTINE BESILATE Properties

Melting point 161-163°
alpha D20 +6.0° (c = 5 in methanol)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form Solid
color White to Light Beige
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

BEPOTASTINE BESILATE Chemical Properties,Uses,Production

Description

Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh marketed non-sedating histamine H1 antagonist. Its very low sedative side effect is due to very poor penetration in the central nervous system. Besides its potent and long-acting activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD4 in tracheal smooth muscle and ileum, IL-5 production by human peripheral blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral blood. As a consequence, it is currently being developed against other allergic and respiratory disorders.

Chemical Properties

Off-White to Light Beige Solid

Uses

Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7

Definition

ChEBI: An organosulfonate salt obtained by combining equimolar amounts of bepotastine and benzenesulfonic acid. A topical, selective and non-sedating histamine (H1) receptor antagonist used for treatment of itching associated with allergic co junctivitis.

BEPOTASTINE BESILATE Preparation Products And Raw materials

Raw materials

Phosphonic acid,(3-methyl-2-oxo-5-heptynyl)-, dimethyl ester Thionyl chloride BENZOFURANCARBOXYLIC ACID Sodium bicarbonate Lithium Aluminum Hydride
Sodium Methoxide CERIUM(III) CHLORIDE HEPTAHYDRATE p-Toluenesulfonic acid monohydrate
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Preparation Products

BEPOTASTINE BESILATE Suppliers

Global( 279)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Anant Pharmaceuticals Pvt Ltd +91-8550986868 +91-9485998001 Haryana, India 460 58 Inquiry
Flax Laboratories +91-9867665132 +91-9867665132 Maharashtra, India 44 58 Inquiry
Metrochem API Private Limited +91-4069069999 +91-4069069999 Telangana, India 78 58 Inquiry
Precise Biopharma Pvt Ltd +91-2267828600 +91-2267828600 Maharashtra, India 46 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Global Calcium Pvt Ltd +91-8050750904 +91-8040554500 Karnataka, India 132 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Bal Pharma Limited +91-8041379581 +91-8041379500 Karnataka, India 20 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
Supplier Advantage
Anant Pharmaceuticals Pvt Ltd 58
Flax Laboratories 58
Metrochem API Private Limited 58
Precise Biopharma Pvt Ltd 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Global Calcium Pvt Ltd 58
Ralington Pharma 58
Bal Pharma Limited 58
Pharma Affiliates 58
A.J Chemicals 58

BEPOTASTINE BESILATE Spectrum

BEPOTASTINE BESILATE(190786-44-8)1HNMR

190786-44-8(BEPOTASTINE BESILATE)Related Search:

sodium phenyl sulfate Isopropyl Benzenesulfonate Butyl Benzenesulfonate 2-hydroxyethyl benzenesulfonate Methyl benzenesulfonate
Ramelteon 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid Bepotastine Ethyl Ester 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (R)-
Fasudil hydrochloride FMOC-GLY-GLY-GLY-OH 5-alpha-Hydroxy- Laxogenin 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Benzenesulfonamide Ethyl benzenesulphonate
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4-[4-[(4-chlorophenyl)-pyridin-2-ylMethoxy]piperidin-1-yl]butanoic acid benzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1) Benzenesulfonate salt BEPOTASTINE BESILATE (+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate 4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate Talion (TN) Bepotastine Beslilat Bepotastine Besylate 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-, (S)-, monobenzenesulfonate 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, monobenzenesulfonate 4-[4-[(R)-(4-chlorophenyl)-pyridin-2-yl-methoxy]-1-piperidyl]butanoic acid (+)-(S)-4-[4-[1-(4-Chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid benzenesulfonate bepotastine benzenesulfonate salt (S)-4-[4-(4-Chlorophenyl-2-pyridylMethoxy)piperidinyl]butyric Acid Benzenesulfonate 4-[(S)-(4-Chlorophenyl)-2-pyridinylMethoxy]-1-piperidinebutanoic Acid Benzenesulfonate BB Bepotastine Benzenesulfonate Bepreve Talion TAU 284 Bepotastine Beslilate (S)-Bepotastine Besylate Bepotastine Besilate (This product is only available in Japan.) (S)-4-[4-[(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl]butanoic Acid Benzenesulfonate 4-[4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl]butanoic Acid Benzenesulfonate BEPOTASTINE BESILATE USP/EP/BP Betastine besylate Bepotastine Besilate (Bepreve) Bepotastine BesilateQ: What is Bepotastine Besilate Q: What is the CAS Number of Bepotastine Besilate Q: What is the storage condition of Bepotastine Besilate Q: What are the applications of Bepotastine Besilate Benzestatine CS-645 CS-487 (S)-4-(4-((4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid compound with benzenesulfonic acid (1:1) (S)-4-(4-((4-chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid, benzenesulfonic acid 190786-44-8 C21H25ClN2O3C6H6O3S C27H31ClN2O6S 54706 Inhibitors Other APIs Aromatics Drug Analogues Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API Amino Acids & Derivatives Coronavirus