ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Fasudil hydrochloride
Fasudil hydrochloride
- CAS No.
- 105628-07-7
- Chemical Name:
- Fasudil hydrochloride
- Synonyms
- CS-520;HA-1077;FASUDEL;CS-1572;Fasudil-HA;FASUDIL HCL;HA-1077 HCl;FASUDIL, MONOHCL;Fasudil (HA-1077);Fasudil HCl, >=99%
- CBNumber:
- CB6101699
- Molecular Formula:
- C14H18ClN3O2S
- Molecular Weight:
- 327.83
- MOL File:
- 105628-07-7.mol
- Modify Date:
- 2024/5/13 18:00:15
| Melting point | 220.5°; mp 219.3° (Shirotani) |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: >200 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water and dimethyl sulfoxide. Insoluble in ethanol. |
| Merck | 14,3942 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H |
| InChIKey | LFVPBERIVUNMGV-UHFFFAOYSA-N |
| SMILES | N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl |
| CAS DataBase Reference | 105628-07-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36-60 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HM4031166 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga) | |||||||||
| NFPA 704 |
|
Fasudil hydrochloride Chemical Properties,Uses,Production
Description
Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
Uses
vasodilator, potent Rho-kinase inhibitor
Fasudil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 455)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | China | 1615 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5958 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
Related articles
- Applications and Side Effects of Fasudil Hydrochloride
- Fasudil hydrochloride is a potent drug that is receiving increasing attention due to its unique therapeutic properties and app....
- Mar 29，2024
- About the Uses and Side effects of Fasudil hydrochloride
- Fasudil hydrochloride is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the trea....
- Dec 26，2022
105628-07-7(Fasudil hydrochloride)Related Search:
1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE
Fasudil Monohydrochloride
(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL
5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE
HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE
HA-1077
HA-1077 DIHYDROCHLORIDE
FASUDEL
FASUDIL DIHYDROCHLORIDE
FASUDIL HCL
FASUDIL HYDROCHLORIDE
Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
Fasudil Monohydrochloride Salt >99%
Hydrochloride Fasudil
Fasudil (HA-1077)
Fasudil HCl (HA-1077)
Fasudil (HA-1077) HCl
1-(Isoquinolin-5-ylsulfonyl)perhydro-1,4-diazepine hydrochloride
Fasudil HCl, >=99%
Fasudil (HA-1077) hydrochloride
Isoquinoline,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
FASUDIL, MONOHCL
1-(5-ISOQUINOLINYLSULFONYL)HOMOPIPERAZINE DIHYDROCHLORIDE
1-(5-ISOQUINOLINESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, DIHYDROCHLORIDE
1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE 2HCL
1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE DIHYDROCHLORIDE
1-(5-ISOQUINOLINESULFONYL)-HOMOPIPERAZINE HCL
5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride
HA-1077 HCl
CS-520
CS-1572
HA-1077; AT-877; FASUDIL ; FASUDIL HCL
Fasudil-HA
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
FasudilHydrochloride>
1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride
Fasudil hydrochloride USP/EP/BP
Fasudil HydrochlorideQ: What is
Fasudil Hydrochloride Q: What is the CAS Number of
Fasudil Hydrochloride Q: What is the storage condition of
Fasudil Hydrochloride
Hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride
D-Tryptophan methyl ester hydrochloride 14907-27-8
Fasudil hydrochloride hcl
HOMOPIPERAZINE HYDROCHLORIDE
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride , Fasudil HCl
Fasudil (HA-1077) HCl|||HA-1077|||Fasudil HCl|||HA-1077 hydrochloride|||AT-877
105628-07-7
106528-07-7
C14H17N3O2SHCl
C14H17N3O2SClH
BioChemical
Calcium Channel Modulators
Cell Signaling and Neuroscience
Cell Biology
Voltage-gated Ion Channels
Inhibitors and Activators
Ion Channels
Cardiovascular & Blood System Agents
Inhibitors
Inhibitor