Homopiperazine
- CAS No.
- 505-66-8
- Chemical Name:
- Homopiperazine
- Synonyms
- 1,4-DIAZEPANE;HPRZ;Gao Paiqin;HOMOPIPERAZINE;hoMopiperazate;High-piperazine;Homo-Piperazines;AKOS BBS-00004278;1,4-Diazepane 97%;Homopiperazine>
- CBNumber:
- CB7138982
- Molecular Formula:
- C5H12N2
- Molecular Weight:
- 100.16
- MOL File:
- 505-66-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 16:20:44
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 169 °C (lit.) |
| Density | 0.95 |
| refractive index | 1.4378 (estimate) |
| Flash point | 148 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Crystalline Mass |
| pka | 11.02±0.20(Predicted) |
| color | White to light yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 102711 |
| CAS DataBase Reference | 505-66-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Homopiperazine(505-66-8) |
| EPA Substance Registry System | 1H-1,4-Diazepine, hexahydro- (505-66-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H311-H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P361+P364 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 21-34 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3259 8/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | HM3850000 | |||||||||
| F | 3-10-23 | |||||||||
| Hazard Note | Irritant/Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Homopiperazine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H16604 | Homopiperazine 98% | 505-66-8 | 25G | ₹6365.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H16604 | Homopiperazine 98% | 505-66-8 | 100G | ₹12762.68 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H0572 | Homopiperazine min. 98.0 % | 505-66-8 | 25G | ₹5600 | 2022-05-26 | Buy |
Homopiperazine Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline mass
Uses
Homopiperazine is used to prepare 1,4-bis-(2-thiazolyl)-1,4-diazacycloheptane by reacting with 2-bromo-thiazole. It acts as an intermediate for repaglinide and fasudil hydrochloride. It is also used in the preparation of potent H3 receptor antagonists, which is used for the treatment of neurodegenerative conditions. Further, it is used in vesicant, cosmetic, emulsifier and energetic material. It acts as a corrosion inhibitor for iron. In pharmaceuticals, it is employed as antipyretic and reducing blood sugar, adiposity, calm, antipsychotic and anti-nervous.
structure and hydrogen bonding
The conformation of Homopiperazine is shown below, and the N–C–C–N torsion angle of 58.2(4)° confirms that the left-hand end of the molecule has an almost ideal chair-type conformation, which is only slightly distorted by the insertion of the extra atom at the right-hand end. The two nitrogen lone pairs are aligned in opposite directions, which facilitates the formation of a hydrogen-bonded network due to interaction with the NH of adjacent molecules. Crystal data for C5H12N2, M = 100.16 g mol-1, colorless prism, crystal dimensions 0.10 × 0.10 × 0.10 mm3, tetragonal, space group I–42d (No. 122), a = b = 7.208(2), c = 23.094(7) Å, α = β = γ = 90.00°, V = 1199.9(6) Å3, Z = 8, Dcalc = 1.109 g cm-3, T = 93 K, R1 = 0.0637, Rw2 = 0.1633 for 536 reflections with I > 2σ(I), and 37 variables, Rint 0.0374, goodness of fit on F2 1.137. Data have been deposited at the Cambridge Crystallographic Data Centre as CCDC 2049324[1].
References
[1] R. Aitken, A. Slawin, Dheirya K. Sonecha. “Homopiperazine (Hexahydro-1,4-diazepine).” Molbank 2021 1 (2021): M1200.
Homopiperazine Preparation Products And Raw materials
Raw materials
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| SURVIVAL TECHNOLOGIES LIMITED | +91 8108285261 | Gujarat, India | 294 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Catapharma Chemicals Private Limited | 09422770877 | Maharashtra, India | 56 | 58 | Inquiry |
| Vyas Bio Life Sciences Pvt. Ltd | -65546373 | Hyderabad, India | 1213 | 58 | Inquiry |
| Cns Chemicals | 08066085913Ext 735 | Hyderabad, India | 262 | 58 | Inquiry |
| Chiral Chemicals | 91-22-66332438 | Maharashtra, India | 143 | 58 | Inquiry |
| Black Rose Industries Ltd. | 91-22-43337200 | Maharashtra, India | 45 | 58 | Inquiry |
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