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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >AMPA and kainate receptors >Memantine HCl

Memantine HCl

Memantine HCl Structure
CAS No.
41100-52-1
Chemical Name:
Memantine HCl
Synonyms
Memantine hydrochloride;Namenda;Memantin;3,5-dimethyladamantan-1-amine hydrochloride;3,5-dimethyl-1-aminoadamantane hydrochloride;MENANTINE HYDROCHLORIDE;3,5-dimethyladamantan-1-amine;3,5-DIMETHYL-1-ADAMANTANAMINE HYDROCHLORIDE;D-145;Axura
CBNumber:
CB9232635
Molecular Formula:
C12H22ClN
Molecular Weight:
215.76
MOL File:
41100-52-1.mol
Modify Date:
2024/7/11 9:33:58
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Memantine HCl Properties

Melting point 292 °C
storage temp. Inert atmosphere,2-8°C
solubility Soluble in Water (up to 20 mg/ml)
form Fine Powder
color White
Water Solubility Soluble in water (100mM)
Merck 14,5806
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
InChI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey LDDHMLJTFXJGPI-UHFFFAOYSA-N
SMILES C12(N)CC3(C)CC(CC(C)(C3)C1)C2.[H]Cl
CAS DataBase Reference 41100-52-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29213000
NFPA 704
0
2 0

Memantine HCl price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M9292 Memantine hydrochloride ≥98% (GC) 41100-52-1 25MG ₹8183.7 2022-06-14 Buy
Sigma-Aldrich(India) PHR1886 Memantine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 41100-52-1 1G ₹22743.33 2022-06-14 Buy
Sigma-Aldrich(India) M9292 Memantine hydrochloride ≥98% (GC) 41100-52-1 100MG ₹21030 2022-06-14 Buy
TCI Chemicals (India) D3608 3,5-Dimethyl-1-adamantanamine Hydrochloride 41100-52-1 5G ₹12700 2022-05-26 Buy
TCI Chemicals (India) D3608 3,5-Dimethyl-1-adamantanamine Hydrochloride 41100-52-1 25G ₹23400 2022-05-26 Buy
Product number Packaging Price Buy
M9292 25MG ₹8183.7 Buy
PHR1886 1G ₹22743.33 Buy
M9292 100MG ₹21030 Buy
D3608 5G ₹12700 Buy
D3608 25G ₹23400 Buy

Memantine HCl Chemical Properties,Uses,Production

Description

Memantine, a NMDA receptor antagonist, was co-developed by Forest Laboratories with Merz Pharmaceuticals and marketed under the trade name Namenda for the treatment of Alzheimer’s disease in the US after its approval in October, 2003. This drug has been available in many European and Asian markets before getting approval in the US.

Chemical Properties

Crystalline Solid

Uses

Used as an antiparkinsonian and antispasmodic

Application

Memantine HCl has been used:

  • as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity.
  • to intraperitoneally inject experimental animal to study its effect on traumatic injury.
  • as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration.

Definition

ChEBI: A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Memantine Hydrochloride is a drug used for treating the Alzheimer′s disease by means of reducing abnormal activity in the brain. It can help patients suffering from dementia as it assists them to think more clearly and perform their chores with ease.

Side effects

Serious side effects:
Allergic reaction. Symptoms can include: swelling of your tongue, lips, or face; shortness of breath; skin rash; hives
Hepatitis (inflammation of the liver). Symptoms can include: yellowing of your skin or the whites of your eyes.
Pancreatitis (inflammation of the pancreas). Symptoms can include: severe nausea; severe abdominal pain.
Change in mental health. Symptoms can include: hallucinations; thoughts of suicide.
Congestive heart failure. Symptoms can include: shortness of breath; swelling in your feet and ankles.

Drug interactions

Drugs used to treat glaucoma:
Taking these drugs with memantine can increase the amount of memantine in your body. This can lead to more side effects. Examples of these drugs include: acetazolamide and methazolamide.
Sodium bicarbonate:
Taking memantine with sodium bicarbonate, which can be used to treat heartburn, can increase the amount of memantine in your body. This can lead to more side effects.
Parkinson’s disease medication:
Amantadine works in a similar way to memantine. Taking them together may lead to increased side effects.
Anesthesia medication:
Ketamine works in a similar way to memantine. Taking them together may lead to increased side effects.
Cough medication:
Dextromethorphan works in a similar way to memantine. Taking them together may lead to increased side effects.

Memantine HCl Preparation Products And Raw materials

Raw materials

Acetamide, 2-chloro-N-(3,5-dimethyltricyclo[3.3.1.13,7]dec-1-yl)- 1-Bromo-3,5-dimethyladamantane 3,5-DiMethyl-1-nitroadaMantane N-(3,5-DiMethyladaMantan-1-yl)forMaMide Memantine
1-Chloro-3,5-dimethyladamantane 1-Actamido-3,5-dimethyladmantane
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Preparation Products

3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride

Memantine HCl Suppliers

Global( 726)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Jigs Chemical ltd +919099003427 Gujarat, India 239 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Global Pharma +91-9819994077 +91-9819994077 Maharashtra, India 34 58 Inquiry
KARPSCHEM LABORATORIES +91-7249203006 +91-7249203006 Maharashtra, India 786 58 Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Hikal Ltd. +91-9538444622 +91-8067356100 Maharashtra, India 31 58 Inquiry
Nosch Labs Pvt Ltd +91-4048557474 +91-9948222287 Hyderabad, India 58 58 Inquiry
Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) +91-4428244254 +91-4428244254 Tamil Nadu, India 28 58 Inquiry
Supplier Advantage
Jigs Chemical ltd 58
Dr. Reddy's Laboratories Ltd 58
Global Pharma 58
KARPSCHEM LABORATORIES 58
Vivimed Labs Ltd 58
Macleods Pharmaceuticals Limited 58
Hetero Drugs Limited 58
Hikal Ltd. 58
Nosch Labs Pvt Ltd 58
Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) 58

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Memantine HCl Spectrum

Memantine HCl(41100-52-1)1HNMR

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MEMANTINE HCL LABOTEST-BB LT00233220 1,3-Dimethyl-5-aminoadamantane hydrochloride 1,3-DIMETHYLAMINOADAMANTANE HYDROCHLORIDE 1-AMINO-3,5-DIMETHYLADAMANTANE HCL 1-AMINO-3,5-DIMETHYLADAMANTANE HYDROCHLORIDE 1-AMINO-3,4-DIMETHYLADAMANTANE HYDROCHLORIDE 3,5-DIMETHYLAMANTADINE HYDROCHLORIDE 3,5-DIMETHYL-1-AMINOADAMANTANE HCL 3,5-DIMETHYL-1-ADAMANTANAMINE 1,3-DiMethyl-5-aMinoadaMantane hydrochloride, 99% 1GR D-145 MeMantine hydrochloride API 1-Amino-3,5-dimethyladamantane Hydrochloride Memantine Hydrochloride MEMANTINE HCL(SH) Ebony fruit extract 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine,hydrochloride (1:1) Memantine HCl (Namenda) Axura Ebixa Ebixia Ebixza Memantine hydrochloride (JAN/USAN) Memantine hydrochloride [USAN] Namenda (TN) Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride Memantine Hydrochloride (150 mg) Memantine hydrochloride, >=99% Dark Plum Fruit extract Menantine HCl 3,5-DIMETHYL-TRICYCLO[3.3.1.13,7]DECAN-1-AMINE HYDROCHLORIDE AKATINOL TIMTEC-BB SBB003390 Akatinol, 3,5-Dimethyltricyclo-[3,3,1,13,7]decan-1-amine, 3,5-Dimethyl-1-adamantanamine 1,3-Dimethyl-5-aminoadamantane EMANTINEHYDROCHLORIDE MemantinHCl 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride 3,5-Dimethyladamantane-1-amine·hydrochloride SUN-Y-7017 Fructus Mume P.E. 1,3-Dimethyl-5-aminoadamantane hydrochloride,99% 3,5-Dimethyladamantanamine Hydrochloride (3,5-dimethyl-1-adamantyl)amine hydrochloride 1,3-Dimethyl-5-aminoadamantane hydrocloride, 99% MEMANTINE HCL(SG) Fructus Mume extract 3,5-Dimethyl-1-adamantanamine hydrochloride, 99%, amantadine derivative Memantine hydrochloride 3,5 Dark Plum Fruit、Smoked Plum、Dark Plum. 3,5-Dimethyl-1-adamantanamineHydrochloride> D-145 (hydrochloride) Memantine hydrochL Memantine hydrochloride Solution in Methanol, 100μg/mL Memantine HCl USP/EP/BP High Purity Memantine Hydrochloride CAS 41100-52-1 in Stock Adamantane Impurity 27 HCl Memantine Hydrochloride (Secondary standard)