Memantine
- CAS No.
- 19982-08-2
- Chemical Name:
- Memantine
- Synonyms
- C13736;MEMANTINE;AKOS BB-9600;AURORA KA-7643;7-DIMETHYLXANTHINE;TIMTEC-BB SBB002574;Memantine USP/EP/BP;Acid salts MeMantine;Memantine hydrochlor;(51052-62-1) memantine
- CBNumber:
- CB7436657
- Molecular Formula:
- C12H21N
- Molecular Weight:
- 179.3
- MOL File:
- 19982-08-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/12 17:13:46
| Melting point | 258 °C |
|---|---|
| Boiling point | 239.8±8.0 °C(Predicted) |
| Density | 1.046 |
| refractive index | nD25 1.4941 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 10.79±0.60(Predicted) |
| color | Colorless Oil to Off-White Waxy |
| BCS Class | 1? |
| CAS DataBase Reference | 19982-08-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
Memantine Chemical Properties,Uses,Production
Uses
Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer''s disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.
Definition
ChEBI: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Biological Activity
An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: increased risk of CNS toxicity with
ketamine – avoid.
Analgesics: increased risk of CNS toxicity with
dextromethorphan – avoid.
Dopaminergics: possibly enhances effects of
dopaminergics and selegiline; increased risk of CNS
toxicity with amantadine – avoid.
Metabolism
Memantine undergoes partial hepatic metabolism to form mainly three polar metabolites which possess minimal NMDA receptor antagonistic activity: the N-glucuronide conjugate, 6-hydroxy memantine, and 1-nitrosodeaminated memantine. Renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption.
Memantine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aparna Pharmaceuticals Pvt.Ltd. | +91-4023352708 +91-4023352708 | Mumbai, India | 18 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Parth Antibiotics Pvt Ltd. | +91 (22) 2562-8329 | New Delhi, India | 173 | 50 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18642 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
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