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FASUDIL

FASUDIL Structure
CAS No.
103745-39-7
Chemical Name:
FASUDIL
Synonyms
at877;FASUDIL;Fasudilum;Fasudil HCI;HA-1077：Eril;FASUDIL USP/EP/BP;Fasudil Hydrchloride;Fasudil hydrochlorid;Fasudilum [inn-latin];H-1077 dihydrochloride
CBNumber:
CB3101698
Molecular Formula:
C14H17N3O2S
Molecular Weight:
291.37
MOL File:
103745-39-7.mol
Modify Date:
2023/5/18 11:31:17
Request For Quotation

FASUDIL Properties

Boiling point 506.2±60.0 °C(Predicted)
Density 1.289±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility H2O: >200 mg/mL
form solid
pka 9.73±0.20(Predicted)
color white
Water Solubility Soluble in water or DMSO
CAS DataBase Reference 103745-39-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
RTECS  HM4031166
HS Code  29334900
Toxicity mouse,LD50,unreported,73500ug/kg (73.5mg/kg),United States Patent Document. Vol. #4678783,

FASUDIL price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 371970 HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. 103745-39-7 1MG ₹14260 2022-06-14 Buy
Product number Packaging Price Buy
371970 1MG ₹14260 Buy

FASUDIL Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.

General Description

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 μM), protein kinase G (Ki = 1.6 μM), and myosin light chain kinase (Ki = 3.6 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

Biological Activity

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.

FASUDIL Preparation Products And Raw materials

Raw materials

Isoquinoline

Preparation Products

Fasudil hydrochloride

FASUDIL Suppliers

Global( 188)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21677 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12460 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CLEARSYNTH LABS LTD. 58
Pharma Affiliates 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Hebei Mojin Biotechnology Co., Ltd 58
SIMAGCHEM CORP 58

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Fasudil Hydrochloride Injection 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE at877 hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE HA 1077, DIHYDROCHLORIDE, 99+% FASUDIL Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)- Fasudilum Fasudilum [inn-latin] HA-1077：Eril 2,3,4,5,6,7-Hexahydro-1-(isoquinolin-5-ylsulfonyl)-1H-1,4-diazepine 5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline H-1077 dihydrochloride HA-1077 Dihydrochloride Salt >99% 1-(5-Isoquinolinesulfonyl)homopiperazine, Dihydrochloride Salt 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline dihydrochloride 5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE Fasudil HCI 5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline Fasudil Hydrchloride Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]- FASUDIL USP/EP/BP Fasudil hydrochlorid High Quality API Intermediate Fasudil (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE 103745-39-7 C14H17N3O2S2HCl C14H17N3O2S2ClH Signalling Protein Kinase Inhibitors and Activators Protein Kinase Angiogenesis and Metastasis Intracellular signaling ERIL APIs