Fasudil hydrochloride manufacturers and suppliers in india

Fasudil hydrochloride

Properties

Melting point:: 220.5°; mp 219.3° (Shirotani)

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: H₂O: >200 mg/mL

form: solid

color: white

Water Solubility: Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.

Merck: 14,3942

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

InChI: InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H

InChIKey: LFVPBERIVUNMGV-UHFFFAOYSA-N

SMILES: N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a

Risk Statements: 22

Safety Statements: 36-60

WGK Germany: 3

RTECS: HM4031166

HS Code: 29339900

Toxicity: LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)

Use

Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.